IL-37b, Human
IL-37b, Human

The purity of IL-37b, Human is greater than 90% as determined by SEC-HPLC.

IL-37b, Human

IL-37b, Human on Bis-Tris PAGE under reduced condition. The purity is greater than 95%.

IL-37b, Human

IL-37 is a unique member of the IL-1 family of cytokines, which functions as a natural suppressor of inflammatory and immune Interleukin-37 (IL-37), a newly described member of IL-1family, functioned as a fundamental inhibitor of innate inflammatory and immune responses. IL-37 has five different isoforms, and IL-37b is the most biologically functional subtype. IL-37b Inhibits PGN Induced Cytokines and Chemokines via the Downregulation of Intracellular Nuclear Factor (NF)-κB, PI3K–Akt, and ERK1/2 Pathways.
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Product Introduction
Species Human
Protein Construction
IL-37b (Val46~Asp218)
Accession # Q9NZH6-1
Purity > 95% as determined by Bis­Tris PAGE
Endotoxin Level Less than 1EU per μg by the LAL method.
Expression System E.coli
Theoretical Molecular Weight 19.30 kDa
Apparent Molecular Weight The protein has a predicted MW of 19.30 kDa same as Bis-Tris PAGE result.
Formulation Lyophilized from 0.22μm filtered solution in 20mM PB, 150mM NaCl, 2mM DTT (pH 7.4).
Reconstitution Centrifuge the tube before opening. Reconstituting to a concentration more than 100 μg/ml is recommended. Dissolve the lyophilized protein in distilled water.
Storage & Stability Upon receiving, the product remains stable for 6 months at -20℃ or below. Upon reconstitution, the product should be stable for 3 months at -80℃. Avoid repeated freeze-thaw cycles.

Examples
  • IL-37b, Human
    • IL-37b, Human

    The purity of IL-37b, Human is greater than 90% as determined by SEC-HPLC.

  • IL-37b, Human
    • IL-37b, Human

    IL-37b, Human on Bis-Tris PAGE under reduced condition. The purity is greater than 95%.


Background
Target Background IL-37 is a unique member of the IL-1 family of cytokines, which functions as a natural suppressor of inflammatory and immune Interleukin-37 (IL-37), a newly described member of IL-1family, functioned as a fundamental inhibitor of innate inflammatory and immune responses. IL-37 has five different isoforms, and IL-37b is the most biologically functional subtype. IL-37b Inhibits PGN Induced Cytokines and Chemokines via the Downregulation of Intracellular Nuclear Factor (NF)-κB, PI3K–Akt, and ERK1/2 Pathways.
Synonyms IL-1F7b; IL-HLa; FIL1 zeta; IL-1X; IL-1F7; IL-1H; IL-1H4; IL-1 zeta; IL-1RP1; FIL1Z; IL1F7; IL1H4; IL1RP1

For research use only. Not intended for human or animal clinical trials, therapeutic or diagnostic use.