IL-3 R Beta/CD131, His, Human
IL-3 R Beta/CD131, His, Human

The purity of IL-3 R Beta/CD131, His, Human is greater than 95% as determined by SEC-HPLC.

IL-3 R Beta/CD131, His, Human

IL-3 R Beta/CD131, His, Human on Bis-Tris PAGE under reduced condition. The purity is greater than 95%.

IL-3 R Beta/CD131, His, Human

IL-3 R Beta/CD131, His, Human, His Tag immobilized on CM5 Chip can bind Human GM-CSF, No Tag with an affinity constant of 4.13 μM as determined in SPR assay (Biacore T200) (QC Test).

IL-3 R Beta/CD131, His, Human

Interleukin-3 receptor (IL-3R) is a heterodimer that comprises an IL-3 specific alpha chain (IL-3R alpha) and a common beta chain (beta C) that is shared with the receptors for granulocyte-macrophage colony-stimulating factor (GM-CSF) and IL-5. The beta c subunit does not bind any cytokine by itself but is involved in the formation of high-affinity functional receptors for IL-5 and GM-CSF. These receptors belong to the cytokine receptor superfamily, but they are structurally and functionally more related to each other and thus make up a distinct subfamily.
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Product Introduction
Species Human
Protein Construction
IL-3 R Beta/CD131 (Thr17-Trp443)
Accession # P32927-1		 His
N-term C-term
Purity > 95% as determined by Bis­Tris PAGE 
Endotoxin Level Less than 1EU per μg by the LAL method.
Biological Activity IL-3 R Beta/CD131, His, Human immobilized on CM5 Chip can bind Human GM­CSF, No Tag in SPR assay (Biacore T200). Test result was comparable to standard batch.
Expression System HEK293
Theoretical Molecular Weight 50.30 kDa
Apparent Molecular Weight Due to glycosylation, the protein migrates to 55-70 kDa based on Bis-Tris PAGE result.
Formulation Lyophilized from 0.22 μm filtered solution in PBS (pH 7.4).
Reconstitution Centrifuge the tube before opening. Reconstituting to a concentration more than 100 μg/ml is recommended. Dissolve the lyophilized protein in distilled water.
Storage & Stability Upon receiving, the product remains stable for 6 months at -20℃ or below. Upon reconstitution, the product should be stable for 3 months at -80℃. Avoid repeated freeze-thaw cycles.

Examples
  • IL-3 R Beta/CD131, His, Human
    • IL-3 R Beta/CD131, His, Human

    The purity of IL-3 R Beta/CD131, His, Human is greater than 95% as determined by SEC-HPLC.

  • IL-3 R Beta/CD131, His, Human
    • IL-3 R Beta/CD131, His, Human

    IL-3 R Beta/CD131, His, Human on Bis-Tris PAGE under reduced condition. The purity is greater than 95%.

  • IL-3 R Beta/CD131, His, Human
    • IL-3 R Beta/CD131, His, Human

    IL-3 R Beta/CD131, His, Human, His Tag immobilized on CM5 Chip can bind Human GM-CSF, No Tag with an affinity constant of 4.13 μM as determined in SPR assay (Biacore T200) (QC Test).


Background
Target Background Interleukin-3 receptor (IL-3R) is a heterodimer that comprises an IL-3 specific alpha chain (IL-3R alpha) and a common beta chain (beta C) that is shared with the receptors for granulocyte-macrophage colony-stimulating factor (GM-CSF) and IL-5. The beta c subunit does not bind any cytokine by itself but is involved in the formation of high-affinity functional receptors for IL-5 and GM-CSF. These receptors belong to the cytokine receptor superfamily, but they are structurally and functionally more related to each other and thus make up a distinct subfamily.
Synonyms CDw131; CD131; CSF2RB; IL3RB; IL5RB; AIC2A; Csfgmrb

For research use only. Not intended for human or animal clinical trials, therapeutic or diagnostic use.