Immobilized IL-25/IL-17E, His, Human, His Tag at 5 μg/ml (100 μl/well) on the plate. Dose response curve for Human IL-17Rc, hFc Tag with the EC50 of 4.64 μg /ml determined by ELISA.
The purity of IL-25/IL-17E, His, Human is greater than 95% as determined by SEC-HPLC.
IL-25/IL-17E, His, Human on Bis-Tris PAGE under reduced condition. The purity is greater than 95%.
IL-25/IL-17E, His, Human, His Tag immobilized on CM5 Chip can bind Human IL-25, His Tag with an affinity constant of 0.81nM as determined in SPR assay (Biacore T200).
IL-25/IL-17E, His, Human
IL-25, also known as IL-17E, is a member of the IL-17 cytokine family mostly produced by epithelial cells and innate immune cells. After binding to the IL-17RB/IL-17RA complex, IL-25 induces downstream signaling responses in epithelial cells and type 2 lymphocytes, which initiates, propagates, and sustains type 2 immunity. The function of IL-25 in allergic diseases such as asthma has been well established, and now also is extended to diseases such as inflammatory bowel disease and cancer.
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