Loaded Human IL-22, His Tag on Anti-His-Biosensor can bind IL-22R alpha 1&IL-10R beta hFc Chimera, Avi, Human, hFc-Avi Tag with an affinity constant of 70.70 nM as determined in BLI assay (Gator® Prime).
Immobilized Human IL-22, His Tag at 5 μg/ml (100 μl/well) on the plate. Dose response curve for Biotinylated IL-22R alpha 1&IL-10R beta hFc Chimera, Avi, Human, hFc Avi Tag with the EC50 of 0.77 μg/ml determined by ELISA.
The purity of IL-22R alpha 1&IL-10R beta hFc Chimera, Avi, Human is greater than 95% as determined by SEC-HPLC.
IL-22R alpha 1&IL-10R beta hFc Chimera, Avi, Human on Bis-Tris PAGE under reduced condition. The purity is greater than 95%.
IL-22R alpha 1&IL-10R beta hFc Chimera, Avi, Human
IL-22Rα1 & IL-10Rβ are receptors for IL-22 and IL-10, mediate the activation of JAK-STAT, MAPK and other signaling pathways, and participate in the process of many inflammatory diseases. IL-22 Rα1 contains cytoplasmic motifs for interactions with signal transduction molecules, but formation of ternary complexes with IL10 Rβ or IL20 Rβ and the respective ligands is required for signal transduction.
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