IL-1R2/IL-1 RII/CD121b hFc Chimera, Human
IL-1R2/IL-1 RII/CD121b HFc Chimera, Human

Immobilized Human IL-1 Beta, His Tag at 5 μg/ml (100 μl/well) on the plate. Dose response curve for IL-1R2/IL-1 RII/CD121b hFc Chimera, Human, hFc Tag with the EC50 of 0.12 μg/ml determined by ELISA.

IL-1R2/IL-1 RII/CD121b HFc Chimera, Human

IL-1R2/IL-1 RII/CD121b hFc Chimera, Human on Bis-Tris PAGE under reduced condition. The purity is greater than 95%.

IL-1R2/IL-1 RII/CD121b HFc Chimera, Human

IL-1R2/IL-1 RII/CD121b hFc Chimera, Human, hFc Tag captured on CM5 Chip via Protein A can bind Human IL-1 Beta, His Tag with an affinity constant of 0.88 nM as determined in SPR assay (Biacore T200).

IL-1R2/IL-1 RII/CD121b hFc Chimera, Human

The IL-1 type II receptor (decoy RII) is a nonsignaling molecule the only established function of which is to capture IL-1 and prevent it from interacting with signaling receptor. The decoy RII is released in a regulated way from the cell surface.
Z05463
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Product Introduction
Species Human
Protein Construction
IL-1R2/IL-1 RII/CD121b (Phe14-Glu343)
Accession # NP_004624.1		 hFc
N-term C-term
Purity > 95% as determined by Bis-Tris PAGE
Endotoxin Level Less than 1EU per μg by the LAL method.
Biological Activity Measured by its binding ability in a functional ELISA. Test result was comparable to standard batch.
Expression System HEK293
Theoretical Molecular Weight 64.4 kDa
Apparent Molecular Weight Due to glycosylation, the protein migrates to 70-80 kDa based on Bis-Tris PAGE result.
Formulation Lyophilized from 0.22μm filtered solution in PBS (pH 7.4).
Reconstitution Centrifuge the tube before opening. Reconstituting to a concentration more than 100 μg/ml is recommended. Dissolve the lyophilized protein in distilled water.
Storage & Stability Upon receiving, the product remains stable for 6 months at -20℃ or below. Upon reconstitution, the product should be stable for 3 months at -80℃. Avoid repeated freeze-thaw cycles.

Examples
  • IL-1R2/IL-1 RII/CD121b HFc Chimera, Human
    • IL-1R2/IL-1 RII/CD121b HFc Chimera, Human

    Immobilized Human IL-1 Beta, His Tag at 5 μg/ml (100 μl/well) on the plate. Dose response curve for IL-1R2/IL-1 RII/CD121b hFc Chimera, Human, hFc Tag with the EC50 of 0.12 μg/ml determined by ELISA.

  • IL-1R2/IL-1 RII/CD121b HFc Chimera, Human
    • IL-1R2/IL-1 RII/CD121b HFc Chimera, Human

    IL-1R2/IL-1 RII/CD121b hFc Chimera, Human on Bis-Tris PAGE under reduced condition. The purity is greater than 95%.

  • IL-1R2/IL-1 RII/CD121b HFc Chimera, Human
    • IL-1R2/IL-1 RII/CD121b HFc Chimera, Human

    IL-1R2/IL-1 RII/CD121b hFc Chimera, Human, hFc Tag captured on CM5 Chip via Protein A can bind Human IL-1 Beta, His Tag with an affinity constant of 0.88 nM as determined in SPR assay (Biacore T200).


Background
Target Background The IL-1 type II receptor (decoy RII) is a nonsignaling molecule the only established function of which is to capture IL-1 and prevent it from interacting with signaling receptor. The decoy RII is released in a regulated way from the cell surface.
Synonyms IL-1R-2; IL-1RT-2; IL-1RT2; CDw121b; IL-1R-beta; CD121b; IL1RB; IL1R2; IL-1 RII; MGC47725; IL-1R-β

For research use only. Not intended for human or animal clinical trials, therapeutic or diagnostic use.