IL-17C, His & Avi, Human
IL-17C, His & Avi, Human

Immobilized IL-17C, His & Avi, Human, His Tag at 1μg/ml (100μl/well) on the plate. Dose response curve for Human IL-17RE, hFc Tag with the EC50 of 3.9ng/ml determined by ELISA.

IL-17C, His & Avi, Human

IL-17C, His & Avi, Human on Bis-Tris PAGE under reduced condition. The purity is greater than 95%.

IL-17C, His & Avi, Human

Human IL-17R alpha, hFc Tag captured on CM5 Chip via Protein A can bind IL-17C, His & Avi, Human, His Tag with an affinity constant of 1.84 μM as determined in SPR assay (Biacore T200).

IL-17C, His & Avi, Human

Interleukin‑17C (IL‑17C) is a 15‑20 kDa glycosylated cytokine that plays an important role in mucosal immunity and chronic inflammation. The six IL‑17 cytokines (IL‑17A‑F) are encoded by separate genes but adopt a conserved cystine knot fold. IL‑17C is Cytokine that plays a crucial role in innate immunity of the epithelium, including to intestinal bacterial pathogens, in an autocrine manner. Stimulates the production of antibacterial peptides and proinflammatory molecules for host defense by signaling through the NF-kappa-B and MAPK pathways. Acts synergically with IL22 in inducing the expression of antibacterial peptides, including S100A8, S100A9, REG3A and REG3G.
Z05446
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Product Introduction
Species Human
Protein Construction
IL-17C (His19-Val197)
Accession # Q9P0M4		 His Avi
N-term C-term
Purity > 90% as determined by Bis­Tris PAGE
Endotoxin Level Less than 1EU per μg by the LAL method.
Biological Activity Measured by its binding ability in a functional ELISA. Test result was comparable to standard batch.
Expression System HEK293
Theoretical Molecular Weight 22.6 kDa
Apparent Molecular Weight Due to glycosylation, the protein migrates to 25-28 kDa based on Bis-Tris PAGE result.
Formulation Lyophilized from 0.22μm filtered solution in 50mM MES, 150mM NaCl (PH 6.0).
Reconstitution Centrifuge the tube before opening. Reconstituting to a concentration more than 100 μg/ml is recommended. Dissolve the lyophilized protein in 50mM MES, 150mM NaCl (PH 6.0).
Storage & Stability Upon receiving, the product remains stable for 6 months at -20℃ or below. Upon reconstitution, the product should be stable for 3 months at -80℃. Avoid repeated freeze-thaw cycles.

Examples
  • IL-17C, His & Avi, Human
    • IL-17C, His & Avi, Human

    Immobilized IL-17C, His & Avi, Human, His Tag at 1μg/ml (100μl/well) on the plate. Dose response curve for Human IL-17RE, hFc Tag with the EC50 of 3.9ng/ml determined by ELISA.

  • IL-17C, His & Avi, Human
    • IL-17C, His & Avi, Human

    IL-17C, His & Avi, Human on Bis-Tris PAGE under reduced condition. The purity is greater than 95%.

  • IL-17C, His & Avi, Human
    • IL-17C, His & Avi, Human

    Human IL-17R alpha, hFc Tag captured on CM5 Chip via Protein A can bind IL-17C, His & Avi, Human, His Tag with an affinity constant of 1.84 μM as determined in SPR assay (Biacore T200).


Background
Target Background Interleukin‑17C (IL‑17C) is a 15‑20 kDa glycosylated cytokine that plays an important role in mucosal immunity and chronic inflammation. The six IL‑17 cytokines (IL‑17A‑F) are encoded by separate genes but adopt a conserved cystine knot fold. IL‑17C is Cytokine that plays a crucial role in innate immunity of the epithelium, including to intestinal bacterial pathogens, in an autocrine manner. Stimulates the production of antibacterial peptides and proinflammatory molecules for host defense by signaling through the NF-kappa-B and MAPK pathways. Acts synergically with IL22 in inducing the expression of antibacterial peptides, including S100A8, S100A9, REG3A and REG3G.
Synonyms CX2; Cytokine CX2; IL17C; IL-17C; IL-17CMGC126884

For research use only. Not intended for human or animal clinical trials, therapeutic or diagnostic use.