IDH1, His, Human

IDH1, His, Human

Isocitrate dehydrogenase (IDH) is a metabolic enzyme that converts isocitrate to α-ketoglutarate (α-KG). Genetic gain-of-function mutations in IDH1 and IDH2 confer a neomorphic activity that allow reduction of α -KG to (R)-2- hydroxyglutarate, the accumulation of which results in the development of cancers like low grade gliomas and leukemia.Isocitrate dehydrogenase 1 (IDH1) is the most frequently mutated metabolic gene in cancer.
Z05396
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Product Introduction
Species Human
Protein Construction
IDH1 (Ser2-Leu414)
Accession # O75874		 His
N-term C-term
Purity > 95% as determined by Bis­Tris PAGE 
Endotoxin Level Less than 1EU per μg by the LAL method.
Expression System E.coli
Theoretical Molecular Weight 47.35 kDa
Apparent Molecular Weight The protein has a predicted MW of 47.35 kDa same as Bis-Tris PAGE result.
Formulation Supplied as 0.22μm filtered solution in 50mM Tris, 200mM NaCl, 1mM DTT, 10% Glycerol (pH 7.5).
Concentration Verified by one or more methods from A280/Bioactivity/BCA/Bradford.
Storage & Stability This product remains stable for 6 months at -80°C or below. Avoid repeated freeze-thaw cycles.

Background
Target Background Isocitrate dehydrogenase (IDH) is a metabolic enzyme that converts isocitrate to α-ketoglutarate (α-KG). Genetic gain-of-function mutations in IDH1 and IDH2 confer a neomorphic activity that allow reduction of α -KG to (R)-2- hydroxyglutarate, the accumulation of which results in the development of cancers like low grade gliomas and leukemia.Isocitrate dehydrogenase 1 (IDH1) is the most frequently mutated metabolic gene in cancer.
Synonyms IDH; IDH1; IDPc; PICD; IDP; DCD; IDH; Isocitrate dehydrogenase; IDCD;

For research use only. Not intended for human or animal clinical trials, therapeutic or diagnostic use.