gp130/CD130/IL-6 R beta, His, Human
Gp130/CD130/IL-6 R Beta, His, Human

Immobilized Human IL-6 R alpha, hFc Tag at 2 μg /ml(100 μl/well) on the Human IL-6, No Tag precoated plate(5 μg /ml). Dose response curve for gp130/CD130/IL-6 R beta, His, Human, His Tag with the EC50 of 51.4ng/ml determined by ELISA.

Gp130/CD130/IL-6 R Beta, His, Human

The purity of gp130/CD130/IL-6 R beta, His, Human is greater than 95% as determined by SEC-HPLC.

Gp130/CD130/IL-6 R Beta, His, Human

gp130/CD130/IL-6 R beta, His, Human on Bis-Tris PAGE under reduced condition. The purity is greater than 95%.

gp130/CD130/IL-6 R beta, His, Human

gp130 is a common signal transducing component of the functional receptor complexes for the interleukin (IL)-6 family of cytokines, ie, IL-6, IL-11, leukemia inhibitory factor (LIF), oncostatin M, ciliary neurotrophic factor, and cardiotrophin-1. These cytokines exhibit pleiotropic biological activities in, for instance, immune, hematopoietic, and neural systems, and function in a redundant manner owing to the shared usage of gp130.
Z05364
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Product Introduction
Species Human
Protein Construction
gp130/CD130/IL-6 R beta (Glu23-Glu619)
Accession # P40189-1		 His
N-term C-term
Purity > 95% as determined by Bis­Tris PAGE
Endotoxin Level Less than 1EU per μg by the LAL method.
Biological Activity Measured by its binding ability in a functional ELISA. Test result was comparable to standard batch.
Expression System HEK293
Theoretical Molecular Weight 68.94 kDa
Apparent Molecular Weight Due to glycosylation, the protein migrates to 80-110 kDa based on Bis-Tris PAGE result.
Formulation Lyophilized from 0.22 μm filtered solution in PBS (pH 7.4).
Reconstitution Centrifuge the tube before opening. Reconstituting to a concentration more than 100 μg/ml is recommended. Dissolve the lyophilized protein in distilled water.
Storage & Stability Upon receiving, the product remains stable for 6 months at -20℃ or below. Upon reconstitution, the product should be stable for 3 months at -80℃. Avoid repeated freeze-thaw cycles.

Examples
  • Gp130/CD130/IL-6 R Beta, His, Human
    • Gp130/CD130/IL-6 R Beta, His, Human

    Immobilized Human IL-6 R alpha, hFc Tag at 2 μg /ml(100 μl/well) on the Human IL-6, No Tag precoated plate(5 μg /ml). Dose response curve for gp130/CD130/IL-6 R beta, His, Human, His Tag with the EC50 of 51.4ng/ml determined by ELISA.

  • Gp130/CD130/IL-6 R Beta, His, Human
    • Gp130/CD130/IL-6 R Beta, His, Human

    The purity of gp130/CD130/IL-6 R beta, His, Human is greater than 95% as determined by SEC-HPLC.

  • Gp130/CD130/IL-6 R Beta, His, Human
    • Gp130/CD130/IL-6 R Beta, His, Human

    gp130/CD130/IL-6 R beta, His, Human on Bis-Tris PAGE under reduced condition. The purity is greater than 95%.


Background
Target Background gp130 is a common signal transducing component of the functional receptor complexes for the interleukin (IL)-6 family of cytokines, ie, IL-6, IL-11, leukemia inhibitory factor (LIF), oncostatin M, ciliary neurotrophic factor, and cardiotrophin-1. These cytokines exhibit pleiotropic biological activities in, for instance, immune, hematopoietic, and neural systems, and function in a redundant manner owing to the shared usage of gp130.
Synonyms gp130; CD130; IL-6 R beta; IL-6R-beta; IL-6RB; CDw130; IL6ST

For research use only. Not intended for human or animal clinical trials, therapeutic or diagnostic use.