GITR Ligand/TNFSF18 Trimer, His & Flag, Human
GITR Ligand/TNFSF18 Trimer, His & Flag, Human

Immobilized GITR Ligand/TNFSF18 Trimer, His & Flag, Human, His Tag at 5 μg/ml(100μl/well) on the plate. Dose response curve for Human GITR, hFc Tag with the EC50 of 36.3ng/ml determined by ELISA.

GITR Ligand/TNFSF18 Trimer, His & Flag, Human

The purity of GITR Ligand/TNFSF18 Trimer, His & Flag, Human is greater than 95% as determined by SEC-HPLC.

GITR Ligand/TNFSF18 Trimer, His & Flag, Human

GITR Ligand/TNFSF18 Trimer, His & Flag, Human on Bis-Tris PAGE under reduced condition. The purity is greater than 95%.

GITR Ligand/TNFSF18 Trimer, His & Flag, Human

Glucocorticoid-induced TNFR-related protein (TNFRSF18, GITR, CD357), expressed by T cells, and its ligand (TNFSF18, GITRL), expressed by myeloid populations, provide co-stimulatory signals that boost T cell activity. Due to the important role that GITR plays in regulating immune functions, agonistic stimulation of GITR is a promising therapeutic concept.
Z05357
¥63,425.00

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Product Introduction
Species Human
Protein Construction
Flag His GITR Ligand/TNFSF18 Trimer (Gln50-Ser177)
Accession # Q9UNG2
N-term C-term
Purity > 95% as determined by Bis­Tris PAGE 
Endotoxin Level Less than 1EU per μg by the LAL method.
Biological Activity Measured by its binding ability in a functional ELISA. Test result was comparable to standard batch.
Expression System HEK293
Theoretical Molecular Weight 47.5 kDa
Apparent Molecular Weight Due to glycosylation, the protein migrates to 50-70 kDa based on Bis-Tris PAGE result.
Formulation Lyophilized from 0.22μm filtered solution in PBS (pH 7.4).
Reconstitution Centrifuge the tube before opening. Reconstituting to a concentration more than 100 μg/ml is recommended. Dissolve the lyophilized protein in distilled water.
Storage & Stability Upon receiving, the product remains stable for 6 months at -20℃ or below. Upon reconstitution, the product should be stable for 3 months at -80℃. Avoid repeated freeze-thaw cycles.

Examples
  • GITR Ligand/TNFSF18 Trimer, His & Flag, Human
    • GITR Ligand/TNFSF18 Trimer, His & Flag, Human

    Immobilized GITR Ligand/TNFSF18 Trimer, His & Flag, Human, His Tag at 5 μg/ml(100μl/well) on the plate. Dose response curve for Human GITR, hFc Tag with the EC50 of 36.3ng/ml determined by ELISA.

  • GITR Ligand/TNFSF18 Trimer, His & Flag, Human
    • GITR Ligand/TNFSF18 Trimer, His & Flag, Human

    The purity of GITR Ligand/TNFSF18 Trimer, His & Flag, Human is greater than 95% as determined by SEC-HPLC.

  • GITR Ligand/TNFSF18 Trimer, His & Flag, Human
    • GITR Ligand/TNFSF18 Trimer, His & Flag, Human

    GITR Ligand/TNFSF18 Trimer, His & Flag, Human on Bis-Tris PAGE under reduced condition. The purity is greater than 95%.


Background
Target Background Glucocorticoid-induced TNFR-related protein (TNFRSF18, GITR, CD357), expressed by T cells, and its ligand (TNFSF18, GITRL), expressed by myeloid populations, provide co-stimulatory signals that boost T cell activity. Due to the important role that GITR plays in regulating immune functions, agonistic stimulation of GITR is a promising therapeutic concept.
Synonyms TNFSF18; AITRL; TL6; GITRL; GITR Ligand

For research use only. Not intended for human or animal clinical trials, therapeutic or diagnostic use.