APCDD1, His, Human
APCDD1, His, Human

APCDD1, His, Human on Bis-Tris PAGE under reduced condition. The purity is greater than 95%.

APCDD1, His, Human

Immobilized APCDD1, His, Human, His Tag at 2 μg/ml (100 μl/well) on the plate. Dose response curve for Anti-APCDD1 Antibody, hFc Tag with the EC50 of 4.0ng/ml determined by ELISA.

APCDD1, His, Human

Adenomatosis polyposis coli downregulated 1 (APCDD1), a negative regulator of Wnt signaling, was examined to understand detailed mechanisms underlying Wnt signaling tooth development. In situ hybridization showed that Apcdd1 was expressed in the condensed mesenchyme at the bud stage, and in the inner enamel epithelium (IEE), including enamel knot (EK) at the cap stage. APCDD1 modulates the gene expression of Wnt- and EK-related signaling molecules at the cap stage of tooth development, and is involved in tooth cusp patterning by modulating the epithelial rearrangement in the IEE.
Z05030
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Product Introduction
Species Human
Protein Construction
APCDD1 (Leu27-His492)
Accession # Q8J025		 His
N-term C-term
Purity > 95% as determined by Bis-Tris PAGE
Endotoxin Level Less than 1EU per μg by the LAL method.
Biological Activity Measured by its binding ability in a functional ELISA. Test result was comparable to standard batch.
Expression System HEK293
Theoretical Molecular Weight 54.4 kDa
Apparent Molecular Weight Due to glycosylation, the protein migrates to 58-68 kDa based on Bis-Tris PAGE result.
Formulation Lyophilized from 0.22μm filtered solution in PBS (pH 7.4).
Reconstitution Centrifuge the tube before opening. Reconstituting to a concentration more than 100 μg/ml is recommended. Dissolve the lyophilized protein in distilled water.
Storage & Stability Upon receiving, the product remains stable for 6 months at -20℃ or below. Upon reconstitution, the product should be stable for 3 months at -80℃. Avoid repeated freeze-thaw cycles.

Examples
  • APCDD1, His, Human
    • APCDD1, His, Human

    APCDD1, His, Human on Bis-Tris PAGE under reduced condition. The purity is greater than 95%.

  • APCDD1, His, Human
    • APCDD1, His, Human

    Immobilized APCDD1, His, Human, His Tag at 2 μg/ml (100 μl/well) on the plate. Dose response curve for Anti-APCDD1 Antibody, hFc Tag with the EC50 of 4.0ng/ml determined by ELISA.


Background
Target Background Adenomatosis polyposis coli downregulated 1 (APCDD1), a negative regulator of Wnt signaling, was examined to understand detailed mechanisms underlying Wnt signaling tooth development. In situ hybridization showed that Apcdd1 was expressed in the condensed mesenchyme at the bud stage, and in the inner enamel epithelium (IEE), including enamel knot (EK) at the cap stage. APCDD1 modulates the gene expression of Wnt- and EK-related signaling molecules at the cap stage of tooth development, and is involved in tooth cusp patterning by modulating the epithelial rearrangement in the IEE.
Synonyms Apcdd1; Drapc1; B7323; FP7019; HHS; HTS; HYPT1

For research use only. Not intended for human or animal clinical trials, therapeutic or diagnostic use.