SOST/Sclerostin, His, Cynomolgus
SOST/Sclerostin, His, Cynomolgus

Immobilized SOST/Sclerostin, His, Cynomolgus, His Tag at 1 μg/ml (100 μl/well) on the plate. Dose response curve for Human LRP-6, mFc Tag with the EC50 of 11.6 ng/ml determined by ELISA.

SOST/Sclerostin, His, Cynomolgus

SOST/Sclerostin, His, Cynomolgus on Bis-Tris PAGE under reduced condition. The purity is greater than 95%.

SOST/Sclerostin, His, Cynomolgus

Immobilized SOST/Sclerostin, His, Cynomolgus, His Tag at 0.2μg/ml (100μl/well) on the plate. Dose response curve for Anti-SOST Antibody, hFc Tag with the EC50 of 10.0ng/ml determined by ELISA.

SOST/Sclerostin, His, Cynomolgus

SOST, also known as sclerostin, is a member of the cerberus/DAN family, a group of secreted glycoproteins characterized by a cysteine-knot motif. SOST is negative regulator of bone growth that acts through inhibition of Wnt signaling and bone formation.
Z04919
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Product Introduction
Species Cynomolgus
Protein Construction
SOST/Sclerostin (Gln69-Tyr258)
Accession # XP_005584428.2		 His
N-term C-term
Purity > 95% as determined by Bis-Tris PAGE
Endotoxin Level Less than 1EU per μg by the LAL method.
Biological Activity Measured by its binding ability in a functional ELISA.Test result was comparable to standard batch.
Expression System HEK293
Theoretical Molecular Weight 22.58 kDa
Apparent Molecular Weight Due to glycosylation, the protein migrates to 30-40 kDa based on Bis-Tris PAGE result.
Formulation Lyophilized from 0.22μm filtered solution in PBS (pH 7.4).
Reconstitution Centrifuge the tube before opening. Reconstituting to a concentration more than 100 μg/ml is recommended. Dissolve the lyophilized protein in distilled water.
Storage & Stability Upon receiving, the product remains stable for 6 months at -20℃ or below. Upon reconstitution, the product should be stable for 3 months at -80℃. Avoid repeated freeze-thaw cycles.

Examples
  • SOST/Sclerostin, His, Cynomolgus
    • SOST/Sclerostin, His, Cynomolgus

    Immobilized SOST/Sclerostin, His, Cynomolgus, His Tag at 1 μg/ml (100 μl/well) on the plate. Dose response curve for Human LRP-6, mFc Tag with the EC50 of 11.6 ng/ml determined by ELISA.

  • SOST/Sclerostin, His, Cynomolgus
    • SOST/Sclerostin, His, Cynomolgus

    SOST/Sclerostin, His, Cynomolgus on Bis-Tris PAGE under reduced condition. The purity is greater than 95%.

  • SOST/Sclerostin, His, Cynomolgus
    • SOST/Sclerostin, His, Cynomolgus

    Immobilized SOST/Sclerostin, His, Cynomolgus, His Tag at 0.2μg/ml (100μl/well) on the plate. Dose response curve for Anti-SOST Antibody, hFc Tag with the EC50 of 10.0ng/ml determined by ELISA.


Background
Target Background SOST, also known as sclerostin, is a member of the cerberus/DAN family, a group of secreted glycoproteins characterized by a cysteine-knot motif. SOST is negative regulator of bone growth that acts through inhibition of Wnt signaling and bone formation.
Synonyms sclerostin; SOST; VBCHsclerosteosis; CDD; DAND6; SOST1; VBCH

For research use only. Not intended for human or animal clinical trials, therapeutic or diagnostic use.