IL-21R, His, Cynomolgus
IL-21R, His, Cynomolgus

Immobilized IL-21R, His, Cynomolgus, No Tag at 2 μg/ml (100 μl/well) on the plate. Dose response curve for Cynomolgus IL-21R, His Tag with the EC50 of 28.3ng/ml determined by ELISA.

IL-21R, His, Cynomolgus

The purity of IL-21R, His, Cynomolgus is greater than 95% as determined by SEC-HPLC.

IL-21R, His, Cynomolgus

IL-21R, His, Cynomolgus on Bis-Tris PAGE under reduced condition. The purity is greater than 95%.

IL-21R, His, Cynomolgus

IL-21 and IL-21R were highly expressed in the lesional skin and peripheral blood of psoriasis patients. IL-21 promoted CD4 T cells proliferation and Th17 cells differentiation and inhibiting Treg cells differentiation by upregulating RORγt expression and downregulating Foxp3 expression, with increased expression and secretion of IL-17A and IL-22.Microbial translocation and the associated immune activation during HIV-1 infection may lead to high expression levels of the IL-21R activation marker in RM B cells, a feature associated with increased apoptosis and a reduced number of these cells in the circulation.
Z04834
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Product Introduction
Species Cynomolgus
Protein Construction
IL-21R (Cys41-Gly254)
Accession # G7Q0S8		 His
N-term C-term
Purity > 95% as determined by Bis­Tris PAGE 
Endotoxin Level Less than 1EU per μg by the LAL method.
Biological Activity Measured by its binding ability in a functional ELISA.Test result was comparable to standard batch.
Expression System HEK293
Theoretical Molecular Weight 25.70 kDa
Apparent Molecular Weight Due to glycosylation, the protein migrates to 40-50 kDa based on Bis-Tris PAGE result.
Formulation Lyophilized from 0.22μm filtered solution in PBS (pH 7.4).
Reconstitution Centrifuge the tube before opening. Reconstituting to a concentration more than 100 μg/ml is recommended. Dissolve the lyophilized protein in distilled water.
Storage & Stability Upon receiving, the product remains stable for 6 months at -20℃ or below. Upon reconstitution, the product should be stable for 3 months at -80℃. Avoid repeated freeze-thaw cycles.

Examples
  • IL-21R, His, Cynomolgus
    • IL-21R, His, Cynomolgus

    Immobilized IL-21R, His, Cynomolgus, No Tag at 2 μg/ml (100 μl/well) on the plate. Dose response curve for Cynomolgus IL-21R, His Tag with the EC50 of 28.3ng/ml determined by ELISA.

  • IL-21R, His, Cynomolgus
    • IL-21R, His, Cynomolgus

    The purity of IL-21R, His, Cynomolgus is greater than 95% as determined by SEC-HPLC.

  • IL-21R, His, Cynomolgus
    • IL-21R, His, Cynomolgus

    IL-21R, His, Cynomolgus on Bis-Tris PAGE under reduced condition. The purity is greater than 95%.


Background
Target Background IL-21 and IL-21R were highly expressed in the lesional skin and peripheral blood of psoriasis patients. IL-21 promoted CD4 T cells proliferation and Th17 cells differentiation and inhibiting Treg cells differentiation by upregulating RORγt expression and downregulating Foxp3 expression, with increased expression and secretion of IL-17A and IL-22.Microbial translocation and the associated immune activation during HIV-1 infection may lead to high expression levels of the IL-21R activation marker in RM B cells, a feature associated with increased apoptosis and a reduced number of these cells in the circulation.
Synonyms IL-21 receptor; IL-21R; CD360; NILR

For research use only. Not intended for human or animal clinical trials, therapeutic or diagnostic use.