The purity of IL-18 R1/CD218a, His, Cynomolgus is greater than 95% as determined by SEC-HPLC.
IL-18 R1/CD218a, His, Cynomolgus on Bis-Tris PAGE under reduced condition. The purity is greater than 95%.
IL-18 R1/CD218a, His, Cynomolgus, His Tag captured on CM5 Chip via anti-his antibody can bind Human IL-18, No Tag with an affinity constant of 2.02 nM as determined in SPR assay (Biacore T200).
IL-18 R1/CD218a, His, Cynomolgus
Interleukin-18 (IL-18) is a member of the interleukin-1 family of cytokines produced constitutively by different cell types and by adipose tissue. Interleukin (IL)-18 was originally discovered as a factor that enhanced IFN-γ production from anti-CD3-stimulated Th1 cells, especially in the presence of IL-12. Upon stimulation with Ag plus IL-12, naïve T cells develop into IL-18 receptor (IL-18R) expressing Th1 cells, which increase IFN-γ production in response to IL-18 stimulation.
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