Loaded IL-13, His, Cynomolgus, His Tag on Anti-His-Biosensor can bind Human IL-13Ra2, hFc Tag with an affinity constant of 0.14 µM as determined in BLI assay (Gator® Prime).
Immobilized IL-13, His, Cynomolgus, His Tag at 5 μg/ml (100 μl/well) on the plate. Dose response curve for Human IL-13Ra2, hFc Tag with the EC50 of 75.8ng/ml determined by ELISA.
The purity of IL-13, His, Cynomolgus is greater than 95% as determined by SEC-HPLC.
IL-13, His, Cynomolgus on Bis-Tris PAGE under reduced condition. The purity is greater than 95%.
IL-13, His, Cynomolgus, His Tag immobilized on CM5 Chip can bind Cynomolgus IL-13, His Tag with an affinity constant of 21.16 nM as determined in SPR assay (Biacore T200).
IL-13, His, Cynomolgus
Interleukin-13 (IL-13) is a monomeric 17 kDa immunoregulatory cytokine that plays a key role in the pathogenesis of allergy, cancer, and tissue fibrosis. It is secreted by several helper T cell subsets, NK cells, mast cells, eosinophils, basophils, and visceral smooth muscle cells. Inhibits inflammatory cytokine production. Synergizes with IL2 in regulating interferon-gamma synthesis. May be critical in regulating inflammatory and immune responses. Positively regulates IL31RA expression in macrophages.
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