IL-12B/p40/NKSF2, His, Cynomolgus
IL-12B/p40/NKSF2, His, Cynomolgus

Immobilized IL-12B/p40/NKSF2, His, Cynomolgus, His Tag at 0.5 μg/ml (100 μl/well) on the plate. Dose response curve for Anti-IL-12B Antibody, hFc Tag with the EC50 of 2.3ng/ml determined by ELISA.

IL-12B/p40/NKSF2, His, Cynomolgus

The purity of IL-12B/p40/NKSF2, His, Cynomolgus is greater than 95% as determined by SEC-HPLC.

IL-12B/p40/NKSF2, His, Cynomolgus

IL-12B/p40/NKSF2, His, Cynomolgus on Bis-Tris PAGE under reduced condition. The purity is greater than 95%.

IL-12B/p40/NKSF2, His, Cynomolgus

Interleukin (IL)‑12B, which encodes the p40 subunit common to IL‑12 and IL‑23, as one of the genes for which expression in fibroblast‑like synoviocytes from patients with rheumatoid arthritis (RA‑FLS) is induced by DcR3.Decoy receptor 3 (DcR3) competitively binds to three ligands, Fas ligand, lymphotoxin‑related inducible ligand that competes for glycoprotein D binding to herpesvirus entry mediator on T cells and tumor necrosis factor‑like ligand 1A (TL1A), to prevent their effects. Recent studies have suggested that DcR3 directly affects cells as a ligand.
Z04825
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Product Introduction
Species Cynomolgus
Protein Construction
IL-12B/p40/NKSF2 (Ile23-Ser328)
Accession # A0A2K5TM36		 His
N-term C-term
Purity > 95% as determined by Bis­Tris PAGE 
Endotoxin Level Less than 1EU per μg by the LAL method.
Biological Activity Measured by its binding ability in a functional ELISA.Test result was comparable to standard batch.
Expression System HEK293
Theoretical Molecular Weight 35.86 kDa
Apparent Molecular Weight Due to glycosylation, the protein migrates to 40-50 kDa based on Bis-Tris PAGE result.
Formulation Lyophilized from 0.22μm filtered solution in PBS (pH 7.4).
Reconstitution Centrifuge the tube before opening. Reconstituting to a concentration more than 100 μg/ml is recommended. Dissolve the lyophilized protein in distilled water.
Storage & Stability Upon receiving, the product remains stable for 6 months at -20℃ or below. Upon reconstitution, the product should be stable for 3 months at -80℃. Avoid repeated freeze-thaw cycles.

Examples
  • IL-12B/p40/NKSF2, His, Cynomolgus
    • IL-12B/p40/NKSF2, His, Cynomolgus

    Immobilized IL-12B/p40/NKSF2, His, Cynomolgus, His Tag at 0.5 μg/ml (100 μl/well) on the plate. Dose response curve for Anti-IL-12B Antibody, hFc Tag with the EC50 of 2.3ng/ml determined by ELISA.

  • IL-12B/p40/NKSF2, His, Cynomolgus
    • IL-12B/p40/NKSF2, His, Cynomolgus

    The purity of IL-12B/p40/NKSF2, His, Cynomolgus is greater than 95% as determined by SEC-HPLC.

  • IL-12B/p40/NKSF2, His, Cynomolgus
    • IL-12B/p40/NKSF2, His, Cynomolgus

    IL-12B/p40/NKSF2, His, Cynomolgus on Bis-Tris PAGE under reduced condition. The purity is greater than 95%.


Background
Target Background Interleukin (IL)‑12B, which encodes the p40 subunit common to IL‑12 and IL‑23, as one of the genes for which expression in fibroblast‑like synoviocytes from patients with rheumatoid arthritis (RA‑FLS) is induced by DcR3.Decoy receptor 3 (DcR3) competitively binds to three ligands, Fas ligand, lymphotoxin‑related inducible ligand that competes for glycoprotein D binding to herpesvirus entry mediator on T cells and tumor necrosis factor‑like ligand 1A (TL1A), to prevent their effects. Recent studies have suggested that DcR3 directly affects cells as a ligand.
Synonyms IL-12B; CLMF p40; IL-12 subunit p40; NKSF2; CLMF; CLMF2; NKS

For research use only. Not intended for human or animal clinical trials, therapeutic or diagnostic use.