Immobilized Human IL-10, No Tag at 2 μg/ml (100 μl/well) on the plate. Dose response curve for IL-10 R alpha, His, Cynomolgus, His Tag with the EC50 of 2.4ng/ml determined by ELISA.
The purity of IL-10 R alpha, His, Cynomolgus is greater than 95% as determined by SEC-HPLC.
IL-10 R alpha, His, Cynomolgus on Bis-Tris PAGE under reduced condition. The purity is greater than 95%.
IL-10 R alpha, His, Cynomolgus, His Tag immobilized on CM5 Chip can bind Cynomolgus IL-10, His Tag with an affinity constant of 0.93 nM as determined in SPR assay (Biacore T200).
IL-10 R alpha, His, Cynomolgus
The interleukin-10 receptor alpha (IL10RA) gene codes for the alpha chain of the IL-10 receptor which binds the cytokine IL-10. IL-10 is an anti-inflammatory cytokine with immunoregulatory function during the pathogenesis of many inflammatory disorders in livestock, including Johne's disease (JD). JD is a chronic enteritis in cattle caused by Mycobacterium avium subsp. paratuberculosis (MAP) and is responsible for significant economic losses to the dairy industry. Several candidate genes including IL10RA have been found to be associated with JD.
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