PVRIG hFc Chimera[Biotin], Avi, Mouse
PVRIG HFc Chimera[Biotin], Avi, Mouse

Immobilized Mouse Nectin-2, His Tag at 2 μg/ml (100 μl/well) on the plate. Dose response curve for PVRIG hFc Chimera[Biotin], Avi, Mouse, hFc Tag with the EC50 of 5.04 μg/ml determined by ELISA.

PVRIG HFc Chimera[Biotin], Avi, Mouse

PVRIG hFc Chimera[Biotin], Avi, Mouse on Bis-Tris PAGE under reduced condition. The purity is greater than 95%.

PVRIG HFc Chimera[Biotin], Avi, Mouse

PVRIG hFc Chimera[Biotin], Avi, Mouse, hFc-Avi Tag captured on CM5 Chip via Protein A can bind Mouse Nectin-2, His Tag with an affinity constant of 2.22 μM as determined in SPR assay (Biacore T200).

PVRIG hFc Chimera[Biotin], Avi, Mouse

Murine PVRIG interacted weakly with poliovirus receptor (PVR) but bound poliovirus receptor-like 2 (PVRL2) strongly, making the latter its principal ligand.PVRIG is an inducible checkpoint receptor and that targeting PVRIG-PVRL2 interactions results in increased CD8+ T-cell function and reduced tumor growth.
Z04679
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Product Introduction
Species Mouse
Protein Construction
PVRIG (Ser35-Asp165)
Accession # A0A1B0GS01		 hFc Avi
N-term C-term
Conjugate Biotin
Purity > 95% as determined by Bis-Tris PAGE
Endotoxin Level Less than 1EU per μg by the LAL method.
Biological Activity Measured by its binding ability in a functional ELISA.Test result was comparable to standard batch.
Expression System HEK293
Theoretical Molecular Weight 42.7 kDa
Apparent Molecular Weight Due to glycosylation, the protein migrates to 55-65 kDa based on Bis-Tris PAGE result.
Formulation Lyophilized from 0.22μm filtered solution in PBS (pH 7.4).
Reconstitution Centrifuge the tube before opening. Reconstituting to a concentration more than 100 μg/ml is recommended. Dissolve the lyophilized protein in distilled water.
Storage & Stability Upon receiving, the product remains stable for 6 months at -20℃ or below. Upon reconstitution, the product should be stable for 3 months at -80℃. Avoid repeated freeze-thaw cycles.

Examples
  • PVRIG HFc Chimera[Biotin], Avi, Mouse
    • PVRIG HFc Chimera[Biotin], Avi, Mouse

    Immobilized Mouse Nectin-2, His Tag at 2 μg/ml (100 μl/well) on the plate. Dose response curve for PVRIG hFc Chimera[Biotin], Avi, Mouse, hFc Tag with the EC50 of 5.04 μg/ml determined by ELISA.

  • PVRIG HFc Chimera[Biotin], Avi, Mouse
    • PVRIG HFc Chimera[Biotin], Avi, Mouse

    PVRIG hFc Chimera[Biotin], Avi, Mouse on Bis-Tris PAGE under reduced condition. The purity is greater than 95%.

  • PVRIG HFc Chimera[Biotin], Avi, Mouse
    • PVRIG HFc Chimera[Biotin], Avi, Mouse

    PVRIG hFc Chimera[Biotin], Avi, Mouse, hFc-Avi Tag captured on CM5 Chip via Protein A can bind Mouse Nectin-2, His Tag with an affinity constant of 2.22 μM as determined in SPR assay (Biacore T200).


Background
Target Background Murine PVRIG interacted weakly with poliovirus receptor (PVR) but bound poliovirus receptor-like 2 (PVRL2) strongly, making the latter its principal ligand.PVRIG is an inducible checkpoint receptor and that targeting PVRIG-PVRL2 interactions results in increased CD8+ T-cell function and reduced tumor growth.
Synonyms C7orf15; CD112R; MGC104322; MGC138297; MGC2463; PVRIG; ALS2CR18; ALS2CR9; LPD; PREL-2; PREL2; RalGDS/AF-6; RMO1

For research use only. Not intended for human or animal clinical trials, therapeutic or diagnostic use.