IL-23 alpha&IL-12 beta[Biotin], His & Avi, Human&Mouse
IL-23 Alpha&IL-12 Beta[Biotin], His & Avi, Human&Mouse

Immobilized IL-23 alpha&IL-12 beta[Biotin], His & Avi, Human&Mouse, His Tag at 1 μg/ml (100 μl/well) on the streptavidin precoated plate(5 μg/ml). Dose response curve for Human IL-23R, mFc Tag with the EC50 of 37.1 ng/ml determined by ELISA.

IL-23 Alpha&IL-12 Beta[Biotin], His & Avi, Human&Mouse

The purity of IL-23 alpha&IL-12 beta[Biotin], His & Avi, Human&Mouse is greater than 95% as determined by SEC-HPLC.

IL-23 Alpha&IL-12 Beta[Biotin], His & Avi, Human&Mouse

IL-23 alpha&IL-12 beta[Biotin], His & Avi, Human&Mouse on Bis-Tris PAGE under reduced condition. The purity is greater than 95%.

IL-23 alpha&IL-12 beta[Biotin], His & Avi, Human&Mouse

Interleukin (IL)-12 and IL-23 belong to the IL-12 type family and are composite cytokines, consisting of the common β subunit p40 and the specific cytokine α subunit p35 and p19, respectively. IL-12 signals via the IL-12Rβ1·IL-12Rβ2 receptor complex, and IL-23 uses also IL-12Rβ1 but engages IL-23R as second receptor.
Z04510
¥156,696.00

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Product Introduction
Species Human&Mouse
Protein Construction
IL-23 alpha & IL-12 beta [Arg20-Pro189 (Human IL-23 alpha) and Met23-Ser335 (Mouse IL-12 beta)]
Accession # Q9NPF7 (Human IL-23 alpha) & P43432-1 (Mouse IL-12 beta)		 His Avi
N-term C-term
Conjugate Biotin
Purity > 95% as determined by Bis­Tris PAGE 
Endotoxin Level Less than 1EU per μg by the LAL method.
Biological Activity Measured by its binding ability in a functional ELISA.Test result was comparable to standard batch.
Expression System HEK293
Theoretical Molecular Weight 21.7 kDa (Human IL-23 alpha) & 35.8 kDa (Mouse IL-12 beta)
Apparent Molecular Weight Due to glycosylation, the protein migrates to 22-25 kDa (Human IL-23 alpha) & 45-60 kDa (Mouse IL-12 beta) based on Bis-Tris PAGE result.
Formulation Lyophilized from 0.22 μm filtered solution in PBS (pH 7.4).
Reconstitution Centrifuge the tube before opening. Reconstituting to a concentration more than 100 μg/ml is recommended. Dissolve the lyophilized protein in distilled water.
Storage & Stability Upon receiving, the product remains stable for 6 months at -20℃ or below. Upon reconstitution, the product should be stable for 3 months at -80℃. Avoid repeated freeze-thaw cycles.

Examples
  • IL-23 Alpha&IL-12 Beta[Biotin], His & Avi, Human&Mouse
    • IL-23 Alpha&IL-12 Beta[Biotin], His & Avi, Human&Mouse

    Immobilized IL-23 alpha&IL-12 beta[Biotin], His & Avi, Human&Mouse, His Tag at 1 μg/ml (100 μl/well) on the streptavidin precoated plate(5 μg/ml). Dose response curve for Human IL-23R, mFc Tag with the EC50 of 37.1 ng/ml determined by ELISA.

  • IL-23 Alpha&IL-12 Beta[Biotin], His & Avi, Human&Mouse
    • IL-23 Alpha&IL-12 Beta[Biotin], His & Avi, Human&Mouse

    The purity of IL-23 alpha&IL-12 beta[Biotin], His & Avi, Human&Mouse is greater than 95% as determined by SEC-HPLC.

  • IL-23 Alpha&IL-12 Beta[Biotin], His & Avi, Human&Mouse
    • IL-23 Alpha&IL-12 Beta[Biotin], His & Avi, Human&Mouse

    IL-23 alpha&IL-12 beta[Biotin], His & Avi, Human&Mouse on Bis-Tris PAGE under reduced condition. The purity is greater than 95%.


Background
Target Background Interleukin (IL)-12 and IL-23 belong to the IL-12 type family and are composite cytokines, consisting of the common β subunit p40 and the specific cytokine α subunit p35 and p19, respectively. IL-12 signals via the IL-12Rβ1·IL-12Rβ2 receptor complex, and IL-23 uses also IL-12Rβ1 but engages IL-23R as second receptor.
Synonyms IL23 alpha; IL12 beta; IL23 alpha&IL12 beta ; IL12 β; IL23 alpha&IL12 β

For research use only. Not intended for human or animal clinical trials, therapeutic or diagnostic use.