Immobilized IL-13[Biotin], His & Avi, Human, His Avi Tag at 5 μg/ml(100 μl/well) on the streptavidin precoated plate(5 μg/ml). Dose response curve for Human IL-13Ra2, hFc Tag with the EC50 of 0.81 μg/ml determined by ELISA.
The purity of IL-13[Biotin], His & Avi, Human is greater than 95% as determined by SEC-HPLC.
IL-13[Biotin], His & Avi, Human on Bis-Tris PAGE under reduced conditions. The purity is greater than 95%.
Human IL-13Ra1, hFc Tag captured on CM5 Chip via Protein A can bind IL-13[Biotin], His & Avi, Human, His Tag with an affinity constant of 25.59 nM as determined in SPR assay (Biacore T200).
IL-13[Biotin], His & Avi, Human
Interleukin-13 (IL-13) is a monomeric 17 kDa immunoregulatory cytokine that plays a key role in the pathogenesis of allergy, cancer, and tissue fibrosis. It is secreted by several helper T cell subsets, NK cells, mast cells, eosinophils, basophils, and visceral smooth muscle cells. Inhibits inflammatory cytokine production. Synergizes with IL2 in regulating interferon-gamma synthesis. May be critical in regulating inflammatory and immune responses. Positively regulates IL31RA expression in macrophages (By similarity).
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