AXL[Biotin], His & Avi, Human
AXL[Biotin], His & Avi, Human

Immobilized AXL[Biotin], His & Avi, Human, His Tag at 2 μg/ml (100 μl/well) on the streptavidin precoated plate(5 μg/ml). Dose response curve for Anti-AXL Antibody, hFc Tag with the EC50 of 10.2 ng/ml determined by ELISA.

AXL[Biotin], His & Avi, Human

The purity of AXL[Biotin], His & Avi, Human is greater than 95% as determined by SEC-HPLC.

AXL[Biotin], His & Avi, Human

AXL[Biotin], His & Avi, Human on Bis-Tris PAGE under reduced condition. The purity is greater than 95%.

AXL[Biotin], His & Avi, Human

Axl, a member of the TAM (Tyro3, Axl, Mer) family, and its inhibitors can specifically break the kinase signaling nodes, allowing advanced patients to regain drug sensitivity with improved therapeutic efficacy. Overexpression and activation of Axl receptor tyrosine kinase have been widely accepted to promote cell proliferation, chemotherapy resistance, invasion, and metastasis in several human cancers, such as lung, breast, and pancreatic cancers.
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Product Introduction
Species Human
Protein Construction
AXL (Ala26-Pro449)
Accession # P30530-1		 His Avi
N-term C-term
Conjugate Biotin
Purity > 95% as determined by Bis­Tris PAGE 
Endotoxin Level Less than 1EU per μg by the LAL method.
Biological Activity Measured by its binding ability in a functional ELISA.Test result was comparable to standard batch.
Expression System HEK293
Theoretical Molecular Weight 48.7 kDa
Apparent Molecular Weight Due to glycosylation, the protein migrates to 70-80 kDa based on Bis-Tris PAGE result.
Formulation Lyophilized from 0.22μm filtered solution in PBS (pH 7.4).
Reconstitution Centrifuge the tube before opening. Reconstituting to a concentration more than 100 μg/ml is recommended. Dissolve the lyophilized protein in distilled water.
Storage & Stability Upon receiving, the product remains stable for 6 months at -20℃ or below. Upon reconstitution, the product should be stable for 3 months at -80℃. Avoid repeated freeze-thaw cycles.

Examples
  • AXL[Biotin], His & Avi, Human
    • AXL[Biotin], His & Avi, Human

    Immobilized AXL[Biotin], His & Avi, Human, His Tag at 2 μg/ml (100 μl/well) on the streptavidin precoated plate(5 μg/ml). Dose response curve for Anti-AXL Antibody, hFc Tag with the EC50 of 10.2 ng/ml determined by ELISA.

  • AXL[Biotin], His & Avi, Human
    • AXL[Biotin], His & Avi, Human

    The purity of AXL[Biotin], His & Avi, Human is greater than 95% as determined by SEC-HPLC.

  • AXL[Biotin], His & Avi, Human
    • AXL[Biotin], His & Avi, Human

    AXL[Biotin], His & Avi, Human on Bis-Tris PAGE under reduced condition. The purity is greater than 95%.


Background
Target Background Axl, a member of the TAM (Tyro3, Axl, Mer) family, and its inhibitors can specifically break the kinase signaling nodes, allowing advanced patients to regain drug sensitivity with improved therapeutic efficacy. Overexpression and activation of Axl receptor tyrosine kinase have been widely accepted to promote cell proliferation, chemotherapy resistance, invasion, and metastasis in several human cancers, such as lung, breast, and pancreatic cancers.
Synonyms Axl; UFO; AXL oncogene; AXL; ARK; JTK11; Tyro7; AI323647; EC 2.7.10; EC 2.7.10.1

For research use only. Not intended for human or animal clinical trials, therapeutic or diagnostic use.