ANGPTL2/Angiopoietin-like 2[Biotin], His & Avi, Human
ANGPTL2/Angiopoietin-like 2[Biotin], His & Avi, Human

The purity of ANGPTL2/Angiopoietin-like 2[Biotin], His & Avi, Human is greater than 95% as determined by SEC-HPLC.

ANGPTL2/Angiopoietin-like 2[Biotin], His & Avi, Human

ANGPTL2/Angiopoietin-like 2[Biotin], His & Avi, Human on Bis-Tris PAGE under reduced condition. The purity is greater than 95%.

ANGPTL2/Angiopoietin-like 2[Biotin], His & Avi, Human

Human LILRB2, hFc Tag captured on CM5 Chip via Protein A can bind ANGPTL2/Angiopoietin-like 2[Biotin], His & Avi, Human, His Tag with an affinity constant of 65.63 nM as determined in SPR assay (Biacore T200).

ANGPTL2/Angiopoietin-like 2[Biotin], His & Avi, Human

Angiopoietin-like 2 (ANGPTL2) is a proinflammatory protein belonging to the angiopoietin-like family. ANGPTL2 is secreted and detected in the systemic circulation. Different observational clinical studies reported that circulating levels of ANGPTL2 increase significantly in various chronic inflammatory diseases and showed associations between ANGPTL2 levels and diagnosis and/or prognosis of cardiovascular diseases, diabetes, chronic kidney disease, and various types of cancers.
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Product Introduction
Species Human
Protein Construction
ANGPTL2/Angiopoietin-like 2 (Thr260-His493)
Accession # Q9UKU9-1		 His Avi
N-term C-term
Conjugate Biotin
Purity > 95% as determined by Bis­Tris PAGE 
Endotoxin Level Less than 1EU per μg by the LAL method.
Biological Activity Human LILRB2, hFc Tag captured on CM5 Chip via Protein A can bind ANGPTL2/Angiopoietin-like 2[Biotin], His & Avi, Human in SPR assay (Biacore T200). Test result was comparable to standard batch.
Expression System HEK293
Theoretical Molecular Weight 30.1 kDa
Apparent Molecular Weight Due to glycosylation, the protein migrates to 31-35 kDa based on Bis-Tris PAGE result.
Formulation Lyophilized from 0.22μm filtered solution in PBS, 200mM L-arginine (pH 7.4).
Reconstitution Centrifuge the tube before opening. Reconstituting to a concentration more than 100 μg/ml is recommended. Dissolve the lyophilized protein in distilled water.
Storage & Stability Upon receiving, the product remains stable for 6 months at -20℃ or below. Upon reconstitution, the product should be stable for 3 months at -80℃. Avoid repeated freeze-thaw cycles.

Examples
  • ANGPTL2/Angiopoietin-like 2[Biotin], His & Avi, Human
    • ANGPTL2/Angiopoietin-like 2[Biotin], His & Avi, Human

    The purity of ANGPTL2/Angiopoietin-like 2[Biotin], His & Avi, Human is greater than 95% as determined by SEC-HPLC.

  • ANGPTL2/Angiopoietin-like 2[Biotin], His & Avi, Human
    • ANGPTL2/Angiopoietin-like 2[Biotin], His & Avi, Human

    ANGPTL2/Angiopoietin-like 2[Biotin], His & Avi, Human on Bis-Tris PAGE under reduced condition. The purity is greater than 95%.

  • ANGPTL2/Angiopoietin-like 2[Biotin], His & Avi, Human
    • ANGPTL2/Angiopoietin-like 2[Biotin], His & Avi, Human

    Human LILRB2, hFc Tag captured on CM5 Chip via Protein A can bind ANGPTL2/Angiopoietin-like 2[Biotin], His & Avi, Human, His Tag with an affinity constant of 65.63 nM as determined in SPR assay (Biacore T200).


Background
Target Background Angiopoietin-like 2 (ANGPTL2) is a proinflammatory protein belonging to the angiopoietin-like family. ANGPTL2 is secreted and detected in the systemic circulation. Different observational clinical studies reported that circulating levels of ANGPTL2 increase significantly in various chronic inflammatory diseases and showed associations between ANGPTL2 levels and diagnosis and/or prognosis of cardiovascular diseases, diabetes, chronic kidney disease, and various types of cancers.
Synonyms ARP2; HARP; angiopoietin-like 2; ANGPTL2; ANGRP2; MGC8889

For research use only. Not intended for human or animal clinical trials, therapeutic or diagnostic use.