IL-18BP[Biotin], His, Cynomolgus

IL-18BP[Biotin], His, Cynomolgus

Cytokines were the first modern immunotherapies to produce durable responses in patients with advanced cancer,components of the interleukin-18 (IL-18) pathway are upregulated on tumour-infiltrating lymphocytes, suggesting that IL-18 therapy could enhance anti-tumour immunity. IL-18BP, a high-affinity IL-18 decoy receptor, is frequently upregulated in diverse human and mouse tumours and limits the anti-tumour activity of IL-18 in mice.
Z04371
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Product Introduction
Species Cynomolgus
Protein Construction
IL-18BP[Biotin] (Thr28-Pro207)
Accession # A0A2K5UDJ4		 His
N-term C-term
Purity > 95% as determined by Bis­Tris PAGE 
Endotoxin Level Less than 1EU per μg by the LAL method.
Biological Activity IL-18BP[Biotin],His, Cynomolgus, His tag captured on CM5 Chip via anti­his antibody can bind Human IL­18, No Tag in SPR assay (Biacore T200). Test result was comparable to standard batch.
Expression System HEK293
Theoretical Molecular Weight 21.14 kDa
Apparent Molecular Weight Due to glycosylation, the protein migrates to 50-65 kDa based on Bis-Tris PAGE result.
Formulation Supplied as 0.22μm filtered solution in PBS (pH 7.4).
Concentration Verified by one or more methods from A280/Bioactivity/BCA/Bradford.
Storage & Stability This product remains stable for 6 months at -80°C or below. Avoid repeated freeze-thaw cycles.

Background
Target Background Cytokines were the first modern immunotherapies to produce durable responses in patients with advanced cancer,components of the interleukin-18 (IL-18) pathway are upregulated on tumour-infiltrating lymphocytes, suggesting that IL-18 therapy could enhance anti-tumour immunity. IL-18BP, a high-affinity IL-18 decoy receptor, is frequently upregulated in diverse human and mouse tumours and limits the anti-tumour activity of IL-18 in mice.
Synonyms IL-18BP; Igifbp; Interleukin-18-binding protein

For research use only. Not intended for human or animal clinical trials, therapeutic or diagnostic use.