IL-17R alpha/CD217 hFc Chimera, Mouse
IL-17R Alpha/CD217 HFc Chimera, Mouse

Immobilized Mouse IL-17A, His Tag at 2 μg/ml (100 μl/well) on the plate. Dose response curve for IL-17R alpha/CD217 hFc Chimera, Mouse, hFc Tag with the EC50 of 30.5ng/ml determined by ELISA.

IL-17R Alpha/CD217 HFc Chimera, Mouse

The purity of IL-17R alpha/CD217 hFc Chimera, Mouse is greater than 95% as determined by SEC-HPLC.

IL-17R Alpha/CD217 HFc Chimera, Mouse

IL-17R alpha/CD217 hFc Chimera, Mouse on Bis-Tris PAGE under reduced condition. The purity is greater than 95%.

IL-17R alpha/CD217 hFc Chimera, Mouse

Interleukin 17 (also known as CTLA‑8) is a T cell‑expressed pleotropic cytokine. IL‑17 binds to IL‑17 receptor (IL‑17 R) which shares no homology with any known family of receptors. While the expression of IL‑17 is restricted to activated T cells, the IL‑17 R mRNA exhibits a broad tissue distribution, and has been detected in virtually all cells and tissues tested. The human IL‑17 R gene was localized to chromosome 22.
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Product Introduction
Species Mouse
Protein Construction
IL-17R alpha/CD217 (Ser32-Trp322)
Accession # Q60943		 hFc
N-term C-term
Purity > 95% as determined by Bis­Tris PAGE 
Endotoxin Level Less than 1EU per ug by the LAL method.
Biological Activity Measured by its binding ability in a functional ELISA.Test result was comparable to standard batch.
Expression System HEK293
Theoretical Molecular Weight 60.1 kDa
Apparent Molecular Weight Due to glycosylation, the protein migrates to 95-110 kDa based on Bis-Tris PAGE result.
Formulation Lyophilized from 0.22μm filtered solution in PBS (pH 7.4).
Reconstitution Centrifuge the tube before opening. Reconstituting to a concentration more than 100 μg/ml is recommended. Dissolve the lyophilized protein in distilled water.
Storage & Stability Upon receiving, the product remains stable for 6 months at -20℃ or below. Upon reconstitution, the product should be stable for 3 months at -80℃. Avoid repeated freeze-thaw cycles.

Examples
  • IL-17R Alpha/CD217 HFc Chimera, Mouse
    • IL-17R Alpha/CD217 HFc Chimera, Mouse

    Immobilized Mouse IL-17A, His Tag at 2 μg/ml (100 μl/well) on the plate. Dose response curve for IL-17R alpha/CD217 hFc Chimera, Mouse, hFc Tag with the EC50 of 30.5ng/ml determined by ELISA.

  • IL-17R Alpha/CD217 HFc Chimera, Mouse
    • IL-17R Alpha/CD217 HFc Chimera, Mouse

    The purity of IL-17R alpha/CD217 hFc Chimera, Mouse is greater than 95% as determined by SEC-HPLC.

  • IL-17R Alpha/CD217 HFc Chimera, Mouse
    • IL-17R Alpha/CD217 HFc Chimera, Mouse

    IL-17R alpha/CD217 hFc Chimera, Mouse on Bis-Tris PAGE under reduced condition. The purity is greater than 95%.


Background
Target Background Interleukin 17 (also known as CTLA‑8) is a T cell‑expressed pleotropic cytokine. IL‑17 binds to IL‑17 receptor (IL‑17 R) which shares no homology with any known family of receptors. While the expression of IL‑17 is restricted to activated T cells, the IL‑17 R mRNA exhibits a broad tissue distribution, and has been detected in virtually all cells and tissues tested. The human IL‑17 R gene was localized to chromosome 22.
Synonyms CD217; CDw217; IL-17RA; IL17R; CANDF5; IL-17R; IL-17R-alpha; IL17Rα

For research use only. Not intended for human or animal clinical trials, therapeutic or diagnostic use.