Nectin-4[Biotin], His & Avi, Human
Nectin-4[Biotin], His & Avi, Human

Immobilized Nectin-4[Biotin], His & Avi, Human, His Tag at 0.5 μg/ml (100 μl/well) on the streptavidin precoated plate (5 μg/ml). Dose response curve for Anti-Nectin-4 Antibody, hFc Tag with the EC50 of 2.0 ng/ml determined by ELISA.

Nectin-4[Biotin], His & Avi, Human

The purity of Nectin-4[Biotin], His & Avi, Human is greater than 95% as determined by SEC-HPLC.

Nectin-4[Biotin], His & Avi, Human

Nectin-4[Biotin], His & Avi, Human on Bis-Tris PAGE under reduced conditions. The purity is greater than 95%.

Nectin-4[Biotin], His & Avi, Human

Nectin-4 seems to be involved in cell adhesion through trans-homophilic and -heterophilic interactions, the latter including specifically interactions with NECTIN1. Does not act as receptor for alpha-herpesvirus entry into cells.(Microbial infection) Acts as a receptor for measles virus.
Z03825
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Product Introduction
Species Human
Protein Construction
Nectin-4 (Gly32-Val351)
Accession # Q96NY8		 His Avi
N-term C-term
Conjugate Biotin
Purity > 95% as determined by Bis-Tris PAGE
Endotoxin Level Less than 1EU per μg by the LAL method.
Biological Activity Measured by its binding ability in a functional ELISA.Test result was comparable to standard batch.
Expression System HEK293
Theoretical Molecular Weight 37.2 kDa
Apparent Molecular Weight Due to glycosylation, the protein migrates to 46-48 kDa based on Bis-Tris PAGE result.
Formulation Lyophilized from a 0.22 μm filtered solution in PBS, pH 7.4.
Reconstitution Centrifuge the tube before opening. Reconstituting to a concentration more than 100 μg/ml is recommended. Dissolve the lyophilized protein in distilled water.
Storage & Stability Upon receiving, the product remains stable for 6 months at -20℃ or below. Upon reconstitution, the product should be stable for 3 months at -80℃. Avoid repeated freeze-thaw cycles.

Examples
  • Nectin-4[Biotin], His & Avi, Human
    • Nectin-4[Biotin], His & Avi, Human

    Immobilized Nectin-4[Biotin], His & Avi, Human, His Tag at 0.5 μg/ml (100 μl/well) on the streptavidin precoated plate (5 μg/ml). Dose response curve for Anti-Nectin-4 Antibody, hFc Tag with the EC50 of 2.0 ng/ml determined by ELISA.

  • Nectin-4[Biotin], His & Avi, Human
    • Nectin-4[Biotin], His & Avi, Human

    The purity of Nectin-4[Biotin], His & Avi, Human is greater than 95% as determined by SEC-HPLC.

  • Nectin-4[Biotin], His & Avi, Human
    • Nectin-4[Biotin], His & Avi, Human

    Nectin-4[Biotin], His & Avi, Human on Bis-Tris PAGE under reduced conditions. The purity is greater than 95%.


Background
Target Background Nectin-4 is a tumor-associated antigen. It is probably involved in cell adhesion through trans-homophilic and -heterophilic interactions. Nectin-4 is overexpressed in urothelial carcinoma and several other malignancies. It is a promising target for antibody-drug conjugates (ADCs).
Synonyms EDSS1; LNIR; Nectin4; PRR4; NECTIN4; PVRL4

For laboratory research use only. Direct human use, including taking orally and injection and clinical use are forbidden.