LCE3B cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	LCE3B
Entrez Gene ID	353143
Full Name	late cornified envelope 3B
Synonyms	LEP14
General protein information	Preferred Names late cornified envelope 3B Names late cornified envelope protein 3B late envelope protein 14
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 1 Map Location: 1q21.3
Disorder MIM:	612614

mRNA and Protein(s)

mRNA	Protein	Name
NM_178433.1	NP_848520.1	late cornified envelope protein 3B

Pathways from BioSystems
Gene Ontology
Bibliography

Related articles in PubMed

Psoriasis-Associated Late Cornified Envelope (LCE) Proteins Have Antibacterial?Activity.
Niehues H, Tsoi LC, van der Krieken DA, Jansen PAM, Oortveld MAW, Rodijk-Olthuis D, van Vlijmen IMJJ, Hendriks WJAJ, Helder RW, Bouwstra JA, van den Bogaard EH, Stuart PE, Nair RP, Elder JT, Zeeuwen PLJM, Schalkwijk J
The Journal of investigative dermatology137(11)2380-2388(2017 Nov)

Increased Risk of Psoriasis due to combined effect of HLA-Cw6 and LCE3 risk alleles in Indian population.
Chandra A, Lahiri A, Senapati S, Basu B, Ghosh S, Mukhopadhyay I, Behra A, Sarkar S, Chatterjee G, Chatterjee R
Scientific reports624059(2016 Apr)

Deletion of late cornified envelope genes, LCE3C_LCE3B-del, is not associated with psoriatic arthritis in Tunisian patients.
Chiraz BS, Myriam A, Ines Z, Catherine J, Fatma B, Ilhem C, Raoudha T, Hela Z, Hela F, Elyes B, Nejib D, Cindy H, Amel E, Slaheddine S
Molecular biology reports41(6)4141-6(2014 Jun)

Failure to find evidence for deletion of LCE3C and LCE3B genes at PSORS4 contributing to psoriasis susceptibility in Tunisian families.
Ammar M, Bouchlaka-Souissi C, Soumaya K, Bouhaha R, Ines Z, Bouazizi F, Doss N, Dhaoui R, Ben Osman A, Ben Ammar-El Gaa?ed A, Mokni M, Marrakchi R
Pathologie-biologie62(1)34-7(2014 Feb)

Association between the LCE3C_LCE3B deletion polymorphism and susceptibility to psoriasis: a meta-analysis of published studies.
Song GG, Kim JH, Lee YH
Genetic testing and molecular biomarkers17(7)572-7(2013 Jul)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

analysis of disease variants at the LCE3 cluster among the psoriasis patients in India
Title: Increased Risk of Psoriasis due to combined effect of HLA-Cw6 and LCE3 risk alleles in Indian population.

Our data suggest that The LCE deletion, previously identified in patients with psoriasis, is not of a major importance in the development of PsA in Tunisian patients
Title: Deletion of late cornified envelope genes, LCE3C_LCE3B-del, is not associated with psoriatic arthritis in Tunisian patients.

No evidence of association was seen between the LCE3C_LCE3B-del and psoriasis in 34 patients from 7 multiplex Tunisian families. No epistasic effect was found between the deletion and PSORS1 locus.
Title: Failure to find evidence for deletion of LCE3C and LCE3B genes at PSORS4 contributing to psoriasis susceptibility in Tunisian families.

Our meta-analysis demonstrates a significant association between psoriasis and the LCE3C_LCE3B-del polymorphism in Europeans and Asians, but no association with psoriatic arthritis.
Title: Association between the LCE3C_LCE3B deletion polymorphism and susceptibility to psoriasis: a meta-analysis of published studies.

The LCE3C_LCE3B-del might play a role in familial psoriasis in the Tunisian population.
Title: Association analysis of LCE3C-LCE3B deletion in Tunisian psoriatic population.

The following LCE3B gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the LCE3B cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
OHu01042	NM_178433.1 Latest version!	Homo sapiens late cornified envelope 3B (LCE3B), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

LCE3B ( NM_178433.1 ) cDNA ORF clone, Homo sapiens(human) -> NP_848520.1 Homo sapiens late cornified envelope 3B (LCE3B), mRNA.

Price & Availability↑

CloneID	OHu01042
Clone ID Related Accession (Same CDS sequence)	NM_178433.1
Accession Version	NM_178433.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 288bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-06-29
Organism	Homo sapiens(human)
Product	late cornified envelope protein 3B
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AL139247.12. Sequence Note: This RefSeq record was created from genomic sequence data because no transcript data was available for this gene. The extent of this transcript is supported by published experimental data. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000335633.1/ ENSP00000335358.1 RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END##

ATGTCCTGCC AGCAGAACCA GCAGCAGTGC CAGCCTCTGC CCAAGTGCCC CTCACCCAAG 
TGCCCCCCAA AGAGCTCAGC ACAGTGTCTG CCTCCAGCCT CCTCCTGCTG TGCTCCAAGA 
CCTGGGTGCT GTGGTGGCCC CAGCTCTGAG GGCGGCTGCT GCCTGAGCCA CCACAGGTGC 
TGCAGGTCCC ACCGATGCCG GCGCCAGAGC TCCAACTCCT GTGACAGAGG CAGTGGTCAG 
CAAGATGGTG CCTCCGACTG TGGCTATGGC TCTGGAGGCT GCTGCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_848520.1
CDS	1..288
Translation	MSCQQNQQQCQPLPKCPSPKCPPKSSAQCLPPASSCCAPRPGCCGGPSSEGGCCLSHHRCCRSHRCRRQSSNSCDRGSGQQDGASDCGYGSGGCC

Target ORF information:

RefSeq Version	NM_178433.1
Organism	Homo sapiens(human)
Definition	Homo sapiens late cornified envelope 3B (LCE3B), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_178433.1

ORF Insert Sequence:

ATGTCCTGCC AGCAGAACCA GCAGCAGTGC CAGCCTCTGC CCAAGTGCCC CTCACCCAAG 
TGCCCCCCAA AGAGCTCAGC ACAGTGTCTG CCTCCAGCCT CCTCCTGCTG TGCTCCAAGA 
CCTGGGTGCT GTGGTGGCCC CAGCTCTGAG GGCGGCTGCT GCCTGAGCCA CCACAGGTGC 
TGCAGGTCCC ACCGATGCCG GCGCCAGAGC TCCAACTCCT GTGACAGAGG CAGTGGTCAG 
CAAGATGGTG CCTCCGACTG TGGCTATGGC TCTGGAGGCT GCTGCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Psoriasis-Associated Late Cornified Envelope (LCE) Proteins Have Antibacterial?Activity.
The Journal of investigative dermatology137(11)2380-2388(2017 Nov)
Niehues H,Tsoi LC,van der Krieken DA,Jansen PAM,Oortveld MAW,Rodijk-Olthuis D,van Vlijmen IMJJ,Hendriks WJAJ,Helder RW,Bouwstra JA,van den Bogaard EH,Stuart PE,Nair RP,Elder JT,Zeeuwen PLJM,Schalkwijk J

Increased Risk of Psoriasis due to combined effect of HLA-Cw6 and LCE3 risk alleles in Indian population.
Scientific reports624059(2016 Apr)
Chandra A,Lahiri A,Senapati S,Basu B,Ghosh S,Mukhopadhyay I,Behra A,Sarkar S,Chatterjee G,Chatterjee R

Deletion of late cornified envelope genes, LCE3C_LCE3B-del, is not associated with psoriatic arthritis in Tunisian patients.
Molecular biology reports41(6)4141-6(2014 Jun)
Chiraz BS,Myriam A,Ines Z,Catherine J,Fatma B,Ilhem C,Raoudha T,Hela Z,Hela F,Elyes B,Nejib D,Cindy H,Amel E,Slaheddine S

Failure to find evidence for deletion of LCE3C and LCE3B genes at PSORS4 contributing to psoriasis susceptibility in Tunisian families.
Pathologie-biologie62(1)34-7(2014 Feb)
Ammar M,Bouchlaka-Souissi C,Soumaya K,Bouhaha R,Ines Z,Bouazizi F,Doss N,Dhaoui R,Ben Osman A,Ben Ammar-El Gaa?ed A,Mokni M,Marrakchi R

Association between the LCE3C_LCE3B deletion polymorphism and susceptibility to psoriasis: a meta-analysis of published studies.
Genetic testing and molecular biomarkers17(7)572-7(2013 Jul)
Song GG,Kim JH,Lee YH