NPC1L1 Antibody, mAb, Rabbit
NPC1L1 Antibody, MAb, Rabbit

Western blot analysis of Niemann Pick C1 Like 1 expression in HeLa cell lysate.

NPC1L1 Antibody, mAb, Rabbit

Plays a major role in cholesterol homeostasis.Critical for the uptake of cholesterol across the plasma membrane of the intestinal enterocyte.Involved in plant sterol absorption, it transports sitosterol, although at lower rates than cholesterol.Is the direct molecular target of ezetimibe, a drug that inhibits cholesterol absorption and is approved for the treatment of hypercholesterolemia.
A04728
¥37,309.00

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Overview
Specificity This product is specific to NPC1L1
Host Species Rabbit
Immunogen A synthesized peptide derived from human NPC1L1
Species Reactivity Human
Conjugate Unconjugated

Applications
Working concentrations for specific applications should be determined by the investigators. The appropriate concentrations may be affected by secondary antibody affinity, antigen concentration, the sensitivity of the method of detection, temperature, the length of the incubations, and other factors. The suitability of this antibody for applications other than those listed below has not been determined. The following concentration ranges are recommended starting points for this product.
Application Recommended Usage
Western Blot 1:1000-1:2000

Properties
Form Liquid
Storage Buffer Supplied in 10mM phosphate buffered saline , pH 7.4, 150mM sodium chloride, 0.05% BSA, 0.02% sodium azide and 50% glycerol.
Storage Instructions Store at -20°C. This product is stable for 1 year upon receipt, when handled and stored as instructed.
Purification Affinity-chromatography
Isotype Rabbit IgG
Clonality Monoclonal

Examples
  • NPC1L1 Antibody, MAb, Rabbit
    • NPC1L1 Antibody, MAb, Rabbit

    Western blot analysis of Niemann Pick C1 Like 1 expression in HeLa cell lysate.


Background
Target Background Plays a major role in cholesterol homeostasis.Critical for the uptake of cholesterol across the plasma membrane of the intestinal enterocyte.Involved in plant sterol absorption, it transports sitosterol, although at lower rates than cholesterol.Is the direct molecular target of ezetimibe, a drug that inhibits cholesterol absorption and is approved for the treatment of hypercholesterolemia.
Synonyms NPC1 LIKE 1; NPC1L1;

For research use only. Not intended for human or animal clinical trials, therapeutic or diagnostic use.