KMT1B Antibody, mAb, Rabbit
KMT1B Antibody, MAb, Rabbit

Western blot analysis of KMT1B / SUV39H2 expression in (1) MOLT-4 cell lysate; (2) Human testis lysate.

KMT1B Antibody, mAb, Rabbit

Histone methyltransferase that specifically trimethylates 'Lys-9' of histone H3 using monomethylated H3 'Lys-9' as substrate. H3 'Lys-9' trimethylation represents a specific tag for epigenetic transcriptional repression by recruiting HP1 (CBX1, CBX3 and/or CBX5) proteins to methylated histones. Mainly functions in heterochromatin regions, thereby playing a central role in the establishment of constitutive heterochromatin at pericentric and telomere regions.
A04504
¥37,309.00

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Overview
Specificity This product is specific to KMT1B
Host Species Rabbit
Immunogen A synthesized peptide derived from human KMT1B
Species Reactivity Human; Mouse; Rat
Conjugate Unconjugated

Applications
Working concentrations for specific applications should be determined by the investigators. The appropriate concentrations may be affected by secondary antibody affinity, antigen concentration, the sensitivity of the method of detection, temperature, the length of the incubations, and other factors. The suitability of this antibody for applications other than those listed below has not been determined. The following concentration ranges are recommended starting points for this product.
Application Recommended Usage
Western Blot 1:1000-1:2000
Immunohistochemistry (IHC) 1:100-1:200
Immunoprecipitation (IP) 1:20-1:50

Properties
Form Liquid
Storage Buffer Supplied in 10mM phosphate buffered saline , pH 7.4, 150mM sodium chloride, 0.05% BSA, 0.02% sodium azide and 50% glycerol.
Storage Instructions Store at -20°C. This product is stable for 1 year upon receipt, when handled and stored as instructed.
Purification Affinity-chromatography
Isotype Rabbit IgG
Clonality Monoclonal

Examples
  • KMT1B Antibody, MAb, Rabbit
    • KMT1B Antibody, MAb, Rabbit

    Western blot analysis of KMT1B / SUV39H2 expression in (1) MOLT-4 cell lysate; (2) Human testis lysate.


Background
Target Background Histone methyltransferase that specifically trimethylates 'Lys-9' of histone H3 using monomethylated H3 'Lys-9' as substrate. H3 'Lys-9' trimethylation represents a specific tag for epigenetic transcriptional repression by recruiting HP1 (CBX1, CBX3 and/or CBX5) proteins to methylated histones. Mainly functions in heterochromatin regions, thereby playing a central role in the establishment of constitutive heterochromatin at pericentric and telomere regions.
Synonyms H3 K9 HMTase 2; KMT1B; Su(var)3 9 homolog 2; Suv39h2;

For research use only. Not intended for human or animal clinical trials, therapeutic or diagnostic use.