UBE3A Antibody, mAb, Rabbit
UBE3A Antibody, MAb, Rabbit

Western blot analysis of UBE3A expression in K562 cell lysate.

UBE3A Antibody, mAb, Rabbit

E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and transfers it to its substrates. Several substrates have been identified including the RAD23A and RAD23B, MCM7 (which is involved in DNA replication), annexin A1, the PML tumor suppressor, and the cell cycle regulator CDKN1B.
A03908
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Overview
Specificity This product is specific to UBE3A
Host Species Rabbit
Immunogen A synthesized peptide derived from human UBE3A
Species Reactivity Human; Mouse; Rat
Conjugate Unconjugated

Applications
Working concentrations for specific applications should be determined by the investigators. The appropriate concentrations may be affected by secondary antibody affinity, antigen concentration, the sensitivity of the method of detection, temperature, the length of the incubations, and other factors. The suitability of this antibody for applications other than those listed below has not been determined. The following concentration ranges are recommended starting points for this product.
Application Recommended Usage
Western Blot 1:1000-1:2000

Properties
Form Liquid
Storage Buffer Supplied in 10mM phosphate buffered saline , pH 7.4, 150mM sodium chloride, 0.05% BSA, 0.02% sodium azide and 50% glycerol.
Storage Instructions Store at -20°C. This product is stable for 1 year upon receipt, when handled and stored as instructed.
Purification Affinity-chromatography
Isotype Rabbit IgG
Clonality Monoclonal

Examples
  • UBE3A Antibody, MAb, Rabbit
    • UBE3A Antibody, MAb, Rabbit

    Western blot analysis of UBE3A expression in K562 cell lysate.


Background
Target Background E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and transfers it to its substrates. Several substrates have been identified including the RAD23A and RAD23B, MCM7 (which is involved in DNA replication), annexin A1, the PML tumor suppressor, and the cell cycle regulator CDKN1B.
Synonyms Ubiquitin-protein ligase E3A; UBE3A; E6AP; EPVE6AP; HPVE6A;

For research use only. Not intended for human or animal clinical trials, therapeutic or diagnostic use.