APEX1 Antibody, mAb, Rabbit
APEX1 Antibody, MAb, Rabbit

Western blot analysis of APE1 expression in K562 cell lysate.

APEX1 Antibody, mAb, Rabbit

Ape1 initiates the repair of abasic sites and is essential for the base excision repair (BER) pathway. Repair activities of Ape1 are stimulated by interaction with XRCC1, another essential protein in BER. Ape1 functions as a redox factor that maintains transcription factors in an active, reduced state but can also function in a redox-independent manner as a transcriptional cofactor to control different cellular fates such as apoptosis, proliferation and differentiation.
A03755
¥37,309.00

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Overview
Specificity This product is specific to APEX1
Host Species Rabbit
Immunogen A synthesized peptide derived from human APEX1
Species Reactivity Human; Mouse; Rat
Conjugate Unconjugated

Applications
Working concentrations for specific applications should be determined by the investigators. The appropriate concentrations may be affected by secondary antibody affinity, antigen concentration, the sensitivity of the method of detection, temperature, the length of the incubations, and other factors. The suitability of this antibody for applications other than those listed below has not been determined. The following concentration ranges are recommended starting points for this product.
Application Recommended Usage
Western Blot 1:1000-1:2000
Immunohistochemistry (IHC) 1:100-1:200

Properties
Form Liquid
Storage Buffer Supplied in 10mM phosphate buffered saline , pH 7.4, 150mM sodium chloride, 0.05% BSA, 0.02% sodium azide and 50% glycerol.
Storage Instructions Store at -20°C. This product is stable for 1 year upon receipt, when handled and stored as instructed.
Purification Affinity-chromatography
Isotype Rabbit IgG
Clonality Monoclonal

Examples
  • APEX1 Antibody, MAb, Rabbit
    • APEX1 Antibody, MAb, Rabbit

    Western blot analysis of APE1 expression in K562 cell lysate.


Background
Target Background Ape1 initiates the repair of abasic sites and is essential for the base excision repair (BER) pathway. Repair activities of Ape1 are stimulated by interaction with XRCC1, another essential protein in BER. Ape1 functions as a redox factor that maintains transcription factors in an active, reduced state but can also function in a redox-independent manner as a transcriptional cofactor to control different cellular fates such as apoptosis, proliferation and differentiation.
Synonyms DNA-(apurinic or apyrimidinic site) lyase; APEX nuclease; APEN; AP endonuclease 1; APE-1; APEX1; APE; APE1; APEX; APX; HAP1; REF1;

For research use only. Not intended for human or animal clinical trials, therapeutic or diagnostic use.