Fev cDNA ORF clone, Mus musculus(house mouse)

Gene
Clones
gRNAs

Summary

Gene Symbol	Fev
Entrez Gene ID	260298
Full Name	FEV (ETS oncogene family)
Synonyms	Pet-1,Pet1,mPet-1
General protein information	Preferred Names FEV (ETS oncogene family) Names protein FEV ETS-domain transcription factor Pet-1 FEV (fifth Ewing variant) PC12 ETS domain-containing transcription factor 1 PC12 ETS factor 1 pheochromocytoma 12 ETS (E26 transformation-specific)
Gene Type	protein-coding
Organism	Mus musculus(house mouse)
Genome	Chromosome: 1 Map Location: 1\|1 C4

mRNA and Protein(s)

mRNA	Protein	Name
XM_017320802.1	XP_017176291.1	protein FEV isoform X1
NM_153111.2	NP_694751.1	protein FEV

Pathways from BioSystems

Homologies

Pan troglodytes (chimpanzee)	FEV	XP_003309530.1
	FEV	XP_001095962.1
Bos taurus (cattle)	FEV	NP_001179532.1
Danio rerio (zebrafish)	fev	NP_001074126.1
Xenopus tropicalis (tropical clawed frog)	fev	XP_002934005.1
Rattus norvegicus (Norway rat)	Fev	NP_653354.2
Homo sapiens (human)	FEV	NP_059991.1
Mus musculus (house mouse)	Fev	NP_694751.1
Gallus gallus (chicken)	LOC100857480	XP_003641694.1

Gene Ontology
Bibliography

Related articles in PubMed

5-hydroxytryptamine synthesized in the aorta-gonad-mesonephros regulates hematopoietic stem and progenitor cell survival.
Lv J, Wang L, Gao Y, Ding YQ, Liu F
The Journal of experimental medicine214(2)529-545(2017 Feb)

Gata2 and Gata3 regulate the differentiation of serotonergic and glutamatergic neuron subtypes of the dorsal raphe.
Haugas M, Tikker L, Achim K, Salminen M, Partanen J
Development (Cambridge, England)143(23)4495-4508(2016 12)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

These results suggest a causal relationship between 5-HT1A and Pet1, and reveal a potential mechanism by which 5-HT1A-Pet1 autoregulatory loop is maintained by serotonin.
Title: Postnatal maintenance of the 5-Ht1a-Pet1 autoregulatory loop by serotonin in the raphe nuclei of the brainstem.

novel evidence for the role of Pet-1 in fear processing and dendritic organization of amygdala neurons
Title: Convergent effects of mouse Pet-1 deletion and human PET-1 variation on amygdala fear and threat processing.

The data of this study indicated that, in addition to transcriptional regulation by Pet-1 in raphe neurons, 5-HT1A receptor expression is regulated indirectly by alterations in 5-HT neurotransmission in a region-specific manner
Title: Region-specific regulation of 5-HT1A receptor expression by Pet-1-dependent mechanisms in vivo.

Pet1-dependent and Pet1-resistant 5-serotonin (5-HT) neurons target different brain centers that might delineate the anatomical basis for a dual serotonergic control on stress responses.
Title: A genetically defined morphologically and functionally unique subset of 5-HT neurons in the mouse raphe nuclei.

This study indicated that Pet-1 is required across the lifespan of the mouse and that behavioral pathogenesis can result from both developmental and adult-onset alterations in serotonergic transcription.
Title: Pet-1 is required across different stages of life to regulate serotonergic function.

The following Fev gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Fev cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
OMu19731	NM_153111.2 Latest version!	Mus musculus FEV transcription factor, ETS family member (Fev), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	TBD	$139.30 $199.00
OMu77137	XM_017320802.1 Latest version!	Mus musculus FEV transcription factor, ETS family member (Fev), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	TBD	$69.30 $99.00

ORF Online Only Promotion

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Fev ( NM_153111.2 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_694751.1 Mus musculus FEV transcription factor, ETS family member (Fev), mRNA.

Price & Availability↑

CloneID	OMu19731
Clone ID Related Accession (Same CDS sequence)	NM_153111.2
Accession Version	NM_153111.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 714bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-24
Organism	Mus musculus(house mouse)
Product	protein FEV
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AC139023.15 and BC138435.1. On May 21, 2009 this sequence version replaced NM_153111.1. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AY049085.1, BC138435.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849377, SAMN00849380 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGAGACAGA GCGGCACCTC CCAGCCCCTG CTGATCAACA TGTACCTGCC AGATCCCGTC 
GGAGATGGTC TTTTTAAGGA AGGGAAGAGC CCGAGCTGGG GGCCGCTGAG CCCCGCGGTA 
CAGAAAGGCA GCGGGCAGAT CCAGTTGTGG CAGTTTCTCC TGGAGCTGCT GGCAGATCGC 
GCGAACGCCG GTTGCATCGC GTGGGAGGGC GGCCACGGCG AGTTCAAGCT CACCGACCCG 
GACGAGGTGG CGCGGCGCTG GGGCGAGCGC AAGAGCAAGC CTAACATGAA CTACGACAAG 
CTAAGTCGCG CGCTGCGCTA CTACTACGAC AAAAACATCA TGAGCAAGGT GCACGGCAAG 
CGCTACGCCT ACCGCTTTGA CTTCCAGGGC CTGGCGCAGG CTTGCCAGCC ACCACCCGCG 
CACGCCCACG CCGCTGCGGC CGCCGCCGCC GCCGCTGCGG CCGCCCAGGA CGGCGCCCTC 
TACAAGCTCC CGGCCGGCCT GGCCCCGCTG CCCTTCCCGG GCCTATCCAA ACTCAACTTG 
ATGGCAGCTT CGGCGGGCGT TGCGCCCGCT GGTTTCTCCT ACTGGCCTGG CCCGAACGCC 
ACCGCCGCTG CCGCCGCCAC CGCCGCGCTC TACCCCACCC CGGGCTTGCA GCCCCCTCCC 
GGGCCCTTCG GCGCAGTGGC GGCAGCTTCG CACTTGGGGG GTCATTATCA CTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_694751.1
CDS	199..912
Translation	MRQSGTSQPLLINMYLPDPVGDGLFKEGKSPSWGPLSPAVQKGSGQIQLWQFLLELLADRANAGCIAWEGGHGEFKLTDPDEVARRWGERKSKPNMNYDKLSRALRYYYDKNIMSKVHGKRYAYRFDFQGLAQACQPPPAHAHAAAAAAAAAAAAQDGALYKLPAGLAPLPFPGLSKLNLMAASAGVAPAGFSYWPGPNATAAAAATAALYPTPGLQPPPGPFGAVAAASHLGGHYH

Target ORF information:

RefSeq Version	NM_153111.2
Organism	Mus musculus(house mouse)
Definition	Mus musculus FEV transcription factor, ETS family member (Fev), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_153111.2

ORF Insert Sequence:

ATGAGACAGA GCGGCACCTC CCAGCCCCTG CTGATCAACA TGTACCTGCC AGATCCCGTC 
GGAGATGGTC TTTTTAAGGA AGGGAAGAGC CCGAGCTGGG GGCCGCTGAG CCCCGCGGTA 
CAGAAAGGCA GCGGGCAGAT CCAGTTGTGG CAGTTTCTCC TGGAGCTGCT GGCAGATCGC 
GCGAACGCCG GTTGCATCGC GTGGGAGGGC GGCCACGGCG AGTTCAAGCT CACCGACCCG 
GACGAGGTGG CGCGGCGCTG GGGCGAGCGC AAGAGCAAGC CTAACATGAA CTACGACAAG 
CTAAGTCGCG CGCTGCGCTA CTACTACGAC AAAAACATCA TGAGCAAGGT GCACGGCAAG 
CGCTACGCCT ACCGCTTTGA CTTCCAGGGC CTGGCGCAGG CTTGCCAGCC ACCACCCGCG 
CACGCCCACG CCGCTGCGGC CGCCGCCGCC GCCGCTGCGG CCGCCCAGGA CGGCGCCCTC 
TACAAGCTCC CGGCCGGCCT GGCCCCGCTG CCCTTCCCGG GCCTATCCAA ACTCAACTTG 
ATGGCAGCTT CGGCGGGCGT TGCGCCCGCT GGTTTCTCCT ACTGGCCTGG CCCGAACGCC 
ACCGCCGCTG CCGCCGCCAC CGCCGCGCTC TACCCCACCC CGGGCTTGCA GCCCCCTCCC 
GGGCCCTTCG GCGCAGTGGC GGCAGCTTCG CACTTGGGGG GTCATTATCA CTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Fev ( XM_017320802.1 ) cDNA ORF clone, Mus musculus(house mouse) -> XP_017176291.1 Mus musculus FEV transcription factor, ETS family member (Fev), transcript variant X1, mRNA.

Price & Availability↑

CloneID	OMu77137
Clone ID Related Accession (Same CDS sequence)	XM_017320802.1
Accession Version	XM_017320802.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 429bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-08-07
Organism	Mus musculus(house mouse)
Product	protein FEV isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000067.6) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Name :: Mus musculus Annotation Release 108 Annotation Version :: 108 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.2 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGAACTACG ACAAGCTAAG TCGCGCGCTG CGCTACTACT ACGACAAAAA CATCATGAGC 
AAGGTGCACG GCAAGCGCTA CGCCTACCGC TTTGACTTCC AGGGCCTGGC GCAGGCTTGC 
CAGCCACCAC CCGCGCACGC CCACGCCGCT GCGGCCGCCG CCGCCGCCGC TGCGGCCGCC 
CAGGACGGCG CCCTCTACAA GCTCCCGGCC GGCCTGGCCC CGCTGCCCTT CCCGGGCCTA 
TCCAAACTCA ACTTGATGGC AGCTTCGGCG GGCGTTGCGC CCGCTGGTTT CTCCTACTGG 
CCTGGCCCGA ACGCCACCGC CGCTGCCGCC GCCACCGCCG CGCTCTACCC CACCCCGGGC 
TTGCAGCCCC CTCCCGGGCC CTTCGGCGCA GTGGCGGCAG CTTCGCACTT GGGGGGTCAT 
TATCACTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_017176291.1
CDS	581..1009
Translation	MNYDKLSRALRYYYDKNIMSKVHGKRYAYRFDFQGLAQACQPPPAHAHAAAAAAAAAAAAQDGALYKLPAGLAPLPFPGLSKLNLMAASAGVAPAGFSYWPGPNATAAAAATAALYPTPGLQPPPGPFGAVAAASHLGGHYH

Target ORF information:

RefSeq Version	XM_017320802.1
Organism	Mus musculus(house mouse)
Definition	Mus musculus FEV transcription factor, ETS family member (Fev), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_017320802.1

ORF Insert Sequence:

ATGAACTACG ACAAGCTAAG TCGCGCGCTG CGCTACTACT ACGACAAAAA CATCATGAGC 
AAGGTGCACG GCAAGCGCTA CGCCTACCGC TTTGACTTCC AGGGCCTGGC GCAGGCTTGC 
CAGCCACCAC CCGCGCACGC CCACGCCGCT GCGGCCGCCG CCGCCGCCGC TGCGGCCGCC 
CAGGACGGCG CCCTCTACAA GCTCCCGGCC GGCCTGGCCC CGCTGCCCTT CCCGGGCCTA 
TCCAAACTCA ACTTGATGGC AGCTTCGGCG GGCGTTGCGC CCGCTGGTTT CTCCTACTGG 
CCTGGCCCGA ACGCCACCGC CGCTGCCGCC GCCACCGCCG CGCTCTACCC CACCCCGGGC 
TTGCAGCCCC CTCCCGGGCC CTTCGGCGCA GTGGCGGCAG CTTCGCACTT GGGGGGTCAT 
TATCACTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

5-hydroxytryptamine synthesized in the aorta-gonad-mesonephros regulates hematopoietic stem and progenitor cell survival.
The Journal of experimental medicine214(2)529-545(2017 Feb)
Lv J,Wang L,Gao Y,Ding YQ,Liu F

Gata2 and Gata3 regulate the differentiation of serotonergic and glutamatergic neuron subtypes of the dorsal raphe.
Development (Cambridge, England)143(23)4495-4508(2016 12)
Haugas M,Tikker L,Achim K,Salminen M,Partanen J