SOX9 cDNA ORF clone, Canis lupus familiaris(dog)

Gene
Clones
gRNAs

Summary

Gene Symbol	SOX9
Entrez Gene ID	403464
Full Name	SRY-box 9
General protein information	Preferred Names SRY-box 9 Names transcription factor SOX-9 SRY (sex determining region Y)-box 9 (campomelic dysplasia, autosomal sex-reversal) SRY-box containing protein 9
Gene Type	protein-coding
Organism	Canis lupus familiaris(dog)

mRNA and Protein(s)

mRNA	Protein	Name
NM_001002978.1	NP_001002978.1	transcription factor SOX-9

Pathways from BioSystems

Homologies

Canis lupus familiaris (dog)	SOX9	NP_001002978.1
Bos taurus (cattle)	SOX9	XP_005221394.1
Xenopus tropicalis (tropical clawed frog)	sox9	NP_001016853.1
	SOX9	NP_001028040.1
Pan troglodytes (chimpanzee)	SOX9	NP_001009029.1
Mus musculus (house mouse)	Sox9	NP_035578.3
Rattus norvegicus (Norway rat)	Sox9	XP_003750998.1
Gallus gallus (chicken)	SOX9	NP_989612.1
Homo sapiens (human)	SOX9	NP_000337.1
Danio rerio (zebrafish)	sox9a	NP_571718.1

Gene Ontology
Bibliography

Related articles in PubMed

Deep sequencing of a candidate region harboring the SOX9 gene for the canine XX disorder of sex development.
Nowacka-Woszuk J, Szczerbal I, Pausch H, Hundi S, Hyt?nen MK, Grzemski A, Flisikowski K, Lohi H, Switonski M, Szydlowski M
Animal genetics48(3)330-337(2017 Jun)

Methylation Patterns of SOX3, SOX9, and WNT4 Genes in Gonads of Dogs with XX (SRY-Negative) Disorder of Sexual Development.
Salamon S, Flisikowski K, Switonski M
Sexual development : genetics, molecular biology, evolution, endocrinology, embryology, and pathology of sex determination and differentiation11(2)86-93(2017)

Copy number variation in the region harboring SOX9 gene in dogs with testicular/ovotesticular disorder of sex development (78,XX; SRY-negative).
Marcinkowska-Swojak M, Szczerbal I, Pausch H, Nowacka-Woszuk J, Flisikowski K, Dzimira S, Nizanski W, Payan-Carreira R, Fries R, Kozlowski P, Switonski M
Scientific reports514696(2015 Oct)

Sox9 expression in canine epithelial skin tumors.
Fantinato E, Milani L, Sironi G
European journal of histochemistry : EJH59(3)2514(2015 Jul)

A Revised Genome Assembly of the Region 5' to Canine SOX9 Includes the RevSex Orthologous Region.
Rossi E, Radi O, De Lorenzi L, Iannuzzi A, Camerino G, Zuffardi O, Parma P
Sexual development : genetics, molecular biology, evolution, endocrinology, embryology, and pathology of sex determination and differentiation9(3)155-61(2015)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

the identified copy number variation region located upstream of the SOX9 gene contains potential regulatory sequences; a multiplication of this element may alter expression of the SOX9 gene, triggering the XX disorder of sex development phenotype
Title: Deep sequencing of a candidate region harboring the SOX9 gene for the canine XX disorder of sex development.

Duplication of SOX9 is not the cause of /ovotesticular disorder of sex development in dogs.
Title: Copy number variation in the region harboring SOX9 gene in dogs with testicular/ovotesticular disorder of sex development (78,XX; SRY-negative).

all the skin neoplasms examined showed a variable positivity to Sox9, especially in the basal layers
Title: Sox9 expression in canine epithelial skin tumors.

the genomic organization in dogs is quite similar to that reported in humans and other mammalian species, including the position of the RevSex region in respect to SOX9.
Title: A Revised Genome Assembly of the Region 5' to Canine SOX9 Includes the RevSex Orthologous Region.

Sox9 duplications are a relevant cause of Sry-negative XX sex reversal
Title: Sox9 duplications are a relevant cause of Sry-negative XX sex reversal dogs.

The following SOX9 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the SOX9 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
OCe00103	NM_001002978.1 Latest version!	Canis lupus familiaris SRY-box transcription factor 9 (SOX9), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	TBD	$342.30 $489.00

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

SOX9 ( NM_001002978.1 ) cDNA ORF clone, Canis lupus familiaris(dog) -> NP_001002978.1 Canis lupus familiaris SRY-box transcription factor 9 (SOX9), mRNA.

Price & Availability↑

CloneID	OCe00103
Clone ID Related Accession (Same CDS sequence)	NM_001002978.1
Accession Version	NM_001002978.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1542bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-07-30
Organism	Canis lupus familiaris(dog)
Product	transcription factor SOX-9
Comment	Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from AY237827.1. ##Evidence-Data-START## Transcript exon combination :: AY237827.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA103936001, SAMEA103936002 [ECO:0000348] ##Evidence-Data-END##

ATGAATCTCC TGGACCCCTT CATGAAGATG ACCGACGAGC AGGAGAAGGG CCTGTCCGGC 
GCCCCCAGCC CCACCATGTC CGAGGACTCG GCGGGCTCGC CCTGCCCTTC GGGCTCCGGC 
TCGGACACCG AGAACACGCG GCCCCAGGAG AACACGTTCC CCAAGGGCGA GCCGGACCTG 
AAGAAGGAGA GCGAGGAGGA CAAGTTCCCC GTGTGCATCC GCGAGGCCGT CAGCCAGGTG 
CTCAAGGGCT ACGACTGGAC GCTGGTGCCC ATGCCCGTGC GCGTCAACGG CTCGAGCAAG 
AACAAGCCGC ACGTCAAGCG GCCCATGAAC GCCTTCATGG TGTGGGCGCA GGCGGCGCGC 
AGGAAGCTCG CCGACCAGTA CCCGCACCTG CACAACGCCG AGCTCAGCAA GACGCTGGGC 
AAGCTCTGGA GGCTGCTGAA CGAGAGCGAG AAGCGGCCCT TCGTGGAGGA GGCGGAGCGG 
CTGCGCGTGC AGCACAAGAA AGACCACCCG GATTACAAGT ACCAGCCGCG GCGGAGGAAG 
TCGGTGAAGA ACGGCCAGGC GGAGGCCGAG GAGGCCACCG AACAGACGCA CATTTCCCCC 
AACGCCATCT TCAAGCGCCT GCAGGCCGAC TCGCCGCACT CCTCCTCCGG CATGAACGAG 
GTGCACTCCC CCGGCAAGCA CTCGGGGCAA TCCCAGGGCC CGCCGACGCC CCCCACCACC 
CCGAAAACCG ACGTGCAGCC GGGCAAGGCT GACCTGAAGC GCGAGGGCCG CCCCCTGCCC 
GAGGGGGGCC GACAGCCCCC CATCGACTTC CGCGACGTGG ACATCGGGGA GCTGAGCAGC 
GACGTCATCT CCAACATAGA GACCTTCGAC GTCAACGAAT TCGACCAGTA CCTGCCGCCC 
AACGGGCACC CCGGGGTGCC GGCCACGCAC GGCCAGGTCA CCTACACGGG CAGCTACGGC 
ATCAGCAGCA CCGCGGCCAC CCCGGCGGGC GCGGGCCACG TGTGGATGTC CAAGCAGCAG 
GCGCCGCCGC CGCCGCCGCC GCCCCCGCAG CAGTCCCCGC AGGCGCCCCC GCAGCCCCCG 
CAGGCGCCCC CGCAGGCCCC GCAGGCGCCC CCGCAGCCGC AGCCCGCGCC CCCGCAGCCG 
CAGGCGGCGC ACACGCTGAC CCCGCTGAGC AGCGAGCCGG GCCAGGCCCA GCGAACGCAC 
ATCAAGACGG AGCAGCTGAG CCCCAGCCAC TACAGCGAGC AGCAGCAGCA CTCGCCGCAG 
CAGATCGCCT ACAGCCCCTT CAGCCTCCCG CACTACAGCC CGTCCTACCC GCCCATCACC 
CGCTCGCAGT ACGACTACAC TGACCACCAG AACTCCGGCT CCTACTACAG CCACGCGGCG 
GGCCAGGGCT CCAGCCTCTA CTCCACCTTC ACCTACATGA ACCCCGCGCA GAGGCCCATG 
TACACCCCCA TCGCCGACAC CTCCGGGGTC CCCTCCATCC CGCAGACGCA CAGCCCCCAG 
CACTGGGAAC AGCCTGTCTA CACACAGCTC ACCAGGCCTT GA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001002978.1
CDS	1..1542
Translation	MNLLDPFMKMTDEQEKGLSGAPSPTMSEDSAGSPCPSGSGSDTENTRPQENTFPKGEPDLKKESEEDKFPVCIREAVSQVLKGYDWTLVPMPVRVNGSSKNKPHVKRPMNAFMVWAQAARRKLADQYPHLHNAELSKTLGKLWRLLNESEKRPFVEEAERLRVQHKKDHPDYKYQPRRRKSVKNGQAEAEEATEQTHISPNAIFKRLQADSPHSSSGMNEVHSPGKHSGQSQGPPTPPTTPKTDVQPGKADLKREGRPLPEGGRQPPIDFRDVDIGELSSDVISNIETFDVNEFDQYLPPNGHPGVPATHGQVTYTGSYGISSTAATPAGAGHVWMSKQQAPPPPPPPPQQSPQAPPQPPQAPPQAPQAPPQPQPAPPQPQAAHTLTPLSSEPGQAQRTHIKTEQLSPSHYSEQQQHSPQQIAYSPFSLPHYSPSYPPITRSQYDYTDHQNSGSYYSHAAGQGSSLYSTFTYMNPAQRPMYTPIADTSGVPSIPQTHSPQHWEQPVYTQLTRP

Target ORF information:

RefSeq Version	NM_001002978.1
Organism	Canis lupus familiaris(dog)
Definition	Canis lupus familiaris SRY-box transcription factor 9 (SOX9), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001002978.1

ORF Insert Sequence:

ATGAATCTCC TGGACCCCTT CATGAAGATG ACCGACGAGC AGGAGAAGGG CCTGTCCGGC 
GCCCCCAGCC CCACCATGTC CGAGGACTCG GCGGGCTCGC CCTGCCCTTC GGGCTCCGGC 
TCGGACACCG AGAACACGCG GCCCCAGGAG AACACGTTCC CCAAGGGCGA GCCGGACCTG 
AAGAAGGAGA GCGAGGAGGA CAAGTTCCCC GTGTGCATCC GCGAGGCCGT CAGCCAGGTG 
CTCAAGGGCT ACGACTGGAC GCTGGTGCCC ATGCCCGTGC GCGTCAACGG CTCGAGCAAG 
AACAAGCCGC ACGTCAAGCG GCCCATGAAC GCCTTCATGG TGTGGGCGCA GGCGGCGCGC 
AGGAAGCTCG CCGACCAGTA CCCGCACCTG CACAACGCCG AGCTCAGCAA GACGCTGGGC 
AAGCTCTGGA GGCTGCTGAA CGAGAGCGAG AAGCGGCCCT TCGTGGAGGA GGCGGAGCGG 
CTGCGCGTGC AGCACAAGAA AGACCACCCG GATTACAAGT ACCAGCCGCG GCGGAGGAAG 
TCGGTGAAGA ACGGCCAGGC GGAGGCCGAG GAGGCCACCG AACAGACGCA CATTTCCCCC 
AACGCCATCT TCAAGCGCCT GCAGGCCGAC TCGCCGCACT CCTCCTCCGG CATGAACGAG 
GTGCACTCCC CCGGCAAGCA CTCGGGGCAA TCCCAGGGCC CGCCGACGCC CCCCACCACC 
CCGAAAACCG ACGTGCAGCC GGGCAAGGCT GACCTGAAGC GCGAGGGCCG CCCCCTGCCC 
GAGGGGGGCC GACAGCCCCC CATCGACTTC CGCGACGTGG ACATCGGGGA GCTGAGCAGC 
GACGTCATCT CCAACATAGA GACCTTCGAC GTCAACGAAT TCGACCAGTA CCTGCCGCCC 
AACGGGCACC CCGGGGTGCC GGCCACGCAC GGCCAGGTCA CCTACACGGG CAGCTACGGC 
ATCAGCAGCA CCGCGGCCAC CCCGGCGGGC GCGGGCCACG TGTGGATGTC CAAGCAGCAG 
GCGCCGCCGC CGCCGCCGCC GCCCCCGCAG CAGTCCCCGC AGGCGCCCCC GCAGCCCCCG 
CAGGCGCCCC CGCAGGCCCC GCAGGCGCCC CCGCAGCCGC AGCCCGCGCC CCCGCAGCCG 
CAGGCGGCGC ACACGCTGAC CCCGCTGAGC AGCGAGCCGG GCCAGGCCCA GCGAACGCAC 
ATCAAGACGG AGCAGCTGAG CCCCAGCCAC TACAGCGAGC AGCAGCAGCA CTCGCCGCAG 
CAGATCGCCT ACAGCCCCTT CAGCCTCCCG CACTACAGCC CGTCCTACCC GCCCATCACC 
CGCTCGCAGT ACGACTACAC TGACCACCAG AACTCCGGCT CCTACTACAG CCACGCGGCG 
GGCCAGGGCT CCAGCCTCTA CTCCACCTTC ACCTACATGA ACCCCGCGCA GAGGCCCATG 
TACACCCCCA TCGCCGACAC CTCCGGGGTC CCCTCCATCC CGCAGACGCA CAGCCCCCAG 
CACTGGGAAC AGCCTGTCTA CACACAGCTC ACCAGGCCTT GA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Deep sequencing of a candidate region harboring the SOX9 gene for the canine XX disorder of sex development.
Animal genetics48(3)330-337(2017 Jun)
Nowacka-Woszuk J,Szczerbal I,Pausch H,Hundi S,Hyt?nen MK,Grzemski A,Flisikowski K,Lohi H,Switonski M,Szydlowski M

Methylation Patterns of SOX3, SOX9, and WNT4 Genes in Gonads of Dogs with XX (SRY-Negative) Disorder of Sexual Development.
Sexual development : genetics, molecular biology, evolution, endocrinology, embryology, and pathology of sex determination and differentiation11(2)86-93(2017)
Salamon S,Flisikowski K,Switonski M

Copy number variation in the region harboring SOX9 gene in dogs with testicular/ovotesticular disorder of sex development (78,XX; SRY-negative).
Scientific reports514696(2015 Oct)
Marcinkowska-Swojak M,Szczerbal I,Pausch H,Nowacka-Woszuk J,Flisikowski K,Dzimira S,Nizanski W,Payan-Carreira R,Fries R,Kozlowski P,Switonski M

Sox9 expression in canine epithelial skin tumors.
European journal of histochemistry : EJH59(3)2514(2015 Jul)
Fantinato E,Milani L,Sironi G

A Revised Genome Assembly of the Region 5' to Canine SOX9 Includes the RevSex Orthologous Region.
Sexual development : genetics, molecular biology, evolution, endocrinology, embryology, and pathology of sex determination and differentiation9(3)155-61(2015)
Rossi E,Radi O,De Lorenzi L,Iannuzzi A,Camerino G,Zuffardi O,Parma P

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SOX9 cDNA ORF clone, Canis lupus familiaris(dog)

Gene

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gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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