Metrnl cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene
Clones
gRNAs

Summary

Gene Symbol	Metrnl
Entrez Gene ID	316842
Full Name	meteorin-like, glial cell differentiation regulator
General protein information	Preferred Names meteorin-like, glial cell differentiation regulator Names meteorin-like protein meteorin, glial cell differentiation regulator-like subfatin
Gene Type	protein-coding
Organism	Rattus norvegicus(Norway rat)
Genome	Chromosome: 10 Map Location: 10q32.3

mRNA and Protein(s)

mRNA	Protein	Name
NM_001014104.1	NP_001014126.1	meteorin-like protein precursor

Pathways from BioSystems

Homologies

Bos taurus (cattle)	METRNL	NP_001192979.1
Homo sapiens (human)	METRNL	NP_001004431.1
Canis lupus familiaris (dog)	METRNL	XP_005642230.1
Rattus norvegicus (Norway rat)	Metrnl	NP_001014126.1
Gallus gallus (chicken)	METRNL	XP_415598.2
Danio rerio (zebrafish)	metrnl	NP_998150.1
Danio rerio (zebrafish)	si:dkey-27j5.3	XP_005160251.1
Mus musculus (house mouse)	Metrnl	NP_659046.1
Pan troglodytes (chimpanzee)	METRNL	XP_001173613.3
	LOC719751	XP_001114398.2
Xenopus tropicalis (tropical clawed frog)	metrnl	NP_001017107.1

Gene Ontology
Bibliography

Related articles in PubMed

Meteorin-like is a hormone that regulates immune-adipose interactions to increase beige fat thermogenesis.
Rao RR, Long JZ, White JP, Svensson KJ, Lou J, Lokurkar I, Jedrychowski MP, Ruas JL, Wrann CD, Lo JC, Camera DM, Lachey J, Gygi S, Seehra J, Hawley JA, Spiegelman BM
Cell157(6)1279-91(2014 Jun)

Subfatin is a novel adipokine and unlike Meteorin in adipose and brain expression.
Li ZY, Zheng SL, Wang P, Xu TY, Guan YF, Zhang YJ, Miao CY
CNS neuroscience & therapeutics20(4)344-54(2014 Apr)

Extracellular matrix secretion by cardiac fibroblasts: role of microRNA-29b and microRNA-30c.
Abonnenc M, Nabeebaccus AA, Mayr U, Barallobre-Barreiro J, Dong X, Cuello F, Sur S, Drozdov I, Langley SR, Lu R, Stathopoulou K, Didangelos A, Yin X, Zimmermann WH, Shah AM, Zampetaki A, Mayr M
Circulation research113(10)1138-47(2013 Oct)

Latent process genes for cell differentiation are common decoders of neurite extension length.
Watanabe K, Akimoto Y, Yugi K, Uda S, Chung J, Nakamuta S, Kaibuchi K, Kuroda S
Journal of cell science125(Pt 9)2198-211(2012 May)

Proteomic analysis of human parotid gland exosomes by multidimensional protein identification technology (MudPIT).
Gonzalez-Begne M, Lu B, Han X, Hagen FK, Hand AR, Melvin JE, Yates JR
Journal of proteome research8(3)1304-14(2009 Mar)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Results show that Subfatin is a novel adipokine regulated by adipogenesis and obesity, with tissue distribution different from its homologue Meteorin
Title: Subfatin is a novel adipokine and unlike Meteorin in adipose and brain expression.

Metrnl, Dclk1 and Serpinb1a have been identified as genes that are induced during the latent process (LP) for cell differentiation with distinct temporal expression profiles and are required for subsequent neurite extension.
Title: Latent process genes for cell differentiation are common decoders of neurite extension length.

The following Metrnl gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Metrnl cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
ORa04982	NM_001014104.1 Latest version!	Rattus norvegicus meteorin-like, glial cell differentiation regulator (Metrnl), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	TBD	$139.30 $199.00

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Metrnl ( NM_001014104.1 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> NP_001014126.1 Rattus norvegicus meteorin-like, glial cell differentiation regulator (Metrnl), mRNA.

Price & Availability↑

CloneID	ORa04982
Clone ID Related Accession (Same CDS sequence)	NM_001014104.1
Accession Version	NM_001014104.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 936bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-24
Organism	Rattus norvegicus(Norway rat)
Product	meteorin-like protein precursor
Comment	Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from BC086590.1. On Apr 20, 2005 this sequence version replaced XM_229276.3. ##Evidence-Data-START## Transcript exon combination :: BC086590.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMD00052296, SAMD00052297 [ECO:0000348] ##Evidence-Data-END##

ATGCGGGGTG TGGTGTGGGC GGCCCGGAGG CGCGCGGGGC AGCAGTGGCC TCGGTCCCCG 
GGCCCTGGGC CGGGTCCGCC CCCGCCGCCA CCGCTGCTGT TGCTGCTACT GCTGCTGCTG 
GGCGGCGCGA GCGCGCAGTA CTCCAGCGAC CTGTGCAGCT GGAAGGGGAG TGGGCTCACC 
CGGGAGGCAC ACAGCAAGGA GGTGGAGCAG GTGTACCTGC GCTGCTCAGC AGGCTCTGTG 
GAATGGATGT ACCCAACCGG GGCGCTCATT GTTAACCTAC GGCCCAACAC CTTCTCACCT 
GCCCAGAACT TGACTGTGTG CATCAAGCCT TTCAGGGACT CCTCTGGGGC CAATATTTAT 
TTGGAAAAAA CTGGAGAACT AAGACTGTTG GTGCGGGATG TCAGAGGCGA ACCTGGCCAA 
GTGCAGTGCT TCAGCCTAGA GCAGGGAGGC TTATTTGTGG AGGCCACACC CCAGCAGGAC 
ATCAGCAGAA GGACCACAGG CTTCCAGTAT GAGCTGATGA GTGGGCAGAG GGGACTGGAC 
CTGCACGTGC TCTCTGCCCC CTGTCGACCT TGCAGCGACA CTGAGGTCCT CCTTGCCATC 
TGCACCAGTG ACTTTGTTGT CCGAGGCTTC ATCGAGGATG TCACCCATGT ACCAGAACAG 
CAAGTGTCAG TCATTCACCT ACGGGTGAGC AGGCTCCACA GGCAGAAGAG CAGGGTCTTC 
CAGCCAGCTC CTGAGGACAG TGGCCACTGG CTGGGCCATG TCACAACACT GTTGCAGTGT 
GGAGTACGAC CAGGGCATGG AGAATTCCTC TTCACTGGAC ATGTGCACTT TGGGGAGGCA 
CAACTTGGAT GTGCCCCACG CTTTAGTGAC TTTCAAAAGA TGTACAGGAA AGCAGAAGAA 
AGGGGCATAA ACCCTTGTGA AATAAATATG GAGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001014126.1
CDS	197..1132
Translation	MRGVVWAARRRAGQQWPRSPGPGPGPPPPPPLLLLLLLLLGGASAQYSSDLCSWKGSGLTREAHSKEVEQVYLRCSAGSVEWMYPTGALIVNLRPNTFSPAQNLTVCIKPFRDSSGANIYLEKTGELRLLVRDVRGEPGQVQCFSLEQGGLFVEATPQQDISRRTTGFQYELMSGQRGLDLHVLSAPCRPCSDTEVLLAICTSDFVVRGFIEDVTHVPEQQVSVIHLRVSRLHRQKSRVFQPAPEDSGHWLGHVTTLLQCGVRPGHGEFLFTGHVHFGEAQLGCAPRFSDFQKMYRKAEERGINPCEINME

Target ORF information:

RefSeq Version	NM_001014104.1
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus meteorin-like, glial cell differentiation regulator (Metrnl), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001014104.1

ORF Insert Sequence:

ATGCGGGGTG TGGTGTGGGC GGCCCGGAGG CGCGCGGGGC AGCAGTGGCC TCGGTCCCCG 
GGCCCTGGGC CGGGTCCGCC CCCGCCGCCA CCGCTGCTGT TGCTGCTACT GCTGCTGCTG 
GGCGGCGCGA GCGCGCAGTA CTCCAGCGAC CTGTGCAGCT GGAAGGGGAG TGGGCTCACC 
CGGGAGGCAC ACAGCAAGGA GGTGGAGCAG GTGTACCTGC GCTGCTCAGC AGGCTCTGTG 
GAATGGATGT ACCCAACCGG GGCGCTCATT GTTAACCTAC GGCCCAACAC CTTCTCACCT 
GCCCAGAACT TGACTGTGTG CATCAAGCCT TTCAGGGACT CCTCTGGGGC CAATATTTAT 
TTGGAAAAAA CTGGAGAACT AAGACTGTTG GTGCGGGATG TCAGAGGCGA ACCTGGCCAA 
GTGCAGTGCT TCAGCCTAGA GCAGGGAGGC TTATTTGTGG AGGCCACACC CCAGCAGGAC 
ATCAGCAGAA GGACCACAGG CTTCCAGTAT GAGCTGATGA GTGGGCAGAG GGGACTGGAC 
CTGCACGTGC TCTCTGCCCC CTGTCGACCT TGCAGCGACA CTGAGGTCCT CCTTGCCATC 
TGCACCAGTG ACTTTGTTGT CCGAGGCTTC ATCGAGGATG TCACCCATGT ACCAGAACAG 
CAAGTGTCAG TCATTCACCT ACGGGTGAGC AGGCTCCACA GGCAGAAGAG CAGGGTCTTC 
CAGCCAGCTC CTGAGGACAG TGGCCACTGG CTGGGCCATG TCACAACACT GTTGCAGTGT 
GGAGTACGAC CAGGGCATGG AGAATTCCTC TTCACTGGAC ATGTGCACTT TGGGGAGGCA 
CAACTTGGAT GTGCCCCACG CTTTAGTGAC TTTCAAAAGA TGTACAGGAA AGCAGAAGAA 
AGGGGCATAA ACCCTTGTGA AATAAATATG GAGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Meteorin-like is a hormone that regulates immune-adipose interactions to increase beige fat thermogenesis.
Cell157(6)1279-91(2014 Jun)
Rao RR,Long JZ,White JP,Svensson KJ,Lou J,Lokurkar I,Jedrychowski MP,Ruas JL,Wrann CD,Lo JC,Camera DM,Lachey J,Gygi S,Seehra J,Hawley JA,Spiegelman BM

Subfatin is a novel adipokine and unlike Meteorin in adipose and brain expression.
CNS neuroscience & therapeutics20(4)344-54(2014 Apr)
Li ZY,Zheng SL,Wang P,Xu TY,Guan YF,Zhang YJ,Miao CY

Extracellular matrix secretion by cardiac fibroblasts: role of microRNA-29b and microRNA-30c.
Circulation research113(10)1138-47(2013 Oct)
Abonnenc M,Nabeebaccus AA,Mayr U,Barallobre-Barreiro J,Dong X,Cuello F,Sur S,Drozdov I,Langley SR,Lu R,Stathopoulou K,Didangelos A,Yin X,Zimmermann WH,Shah AM,Zampetaki A,Mayr M

Latent process genes for cell differentiation are common decoders of neurite extension length.
Journal of cell science125(Pt 9)2198-211(2012 May)
Watanabe K,Akimoto Y,Yugi K,Uda S,Chung J,Nakamuta S,Kaibuchi K,Kuroda S

Proteomic analysis of human parotid gland exosomes by multidimensional protein identification technology (MudPIT).
Journal of proteome research8(3)1304-14(2009 Mar)
Gonzalez-Begne M,Lu B,Han X,Hagen FK,Hand AR,Melvin JE,Yates JR